gene

MAP3K1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAP3K1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

0Hypotheses

0Analyses

1Outgoing

0Incoming

0Experiments

Summary

MAP3K1 (MEKK1) is a serine/threonine kinase at the top of the MAPK signaling cascade, regulating JNK and ERK pathways in neuronal development, stress responses, and neurodegeneration.

View on Wiki →

🧬 Gene Info

Gene Symbol	MAP3K1
Full Name	Mitogen-Activated Protein Kinase Kinase Kinase 1
Aliases	MEKK1
Chromosome	5q11.2.
Protein Type	Serine/Threonine Kinase
Function	is a serine/threonine kinase that functions at the apex of the mitogen-activated protein kinase (MAPK) signaling cascade.
Amino Acids	1643 aa
Exons	24
Pathways	MAPK, MAPK Signaling, MAPK signaling, MAPK pathway
UniProt ID	Q13233
NCBI Gene ID	4214
Ensembl ID	ENSG00000154133
OMIM	600513
GeneCards	MAP3K1
Human Protein Atlas	MAP3K1
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	OPTN
KG Connections	1 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MAP3K1 — AlphaFold Q13233 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    N0["MAP3K1"]
    N1["OPTN"]
    N0 -->|"interacts with"| N1
    N2["neurodegeneration"]
    N0 -->|"implicated in"| N2

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 protein

Outgoing (1)

Target	Relation	Type	Str
OPTN	interacts_with	protein	0.90

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MAP3K1

Understanding Entity Pages

Summary

Wiki Pages (6)

MAP3K1 — Mitogen-Activated Protein Kinase Kinase Kinase 1

MAP2K3 Protein (MEK3)

RNF11 — RING Finger Protein 11

MEKK1 Protein

MAP2K4 — Mitogen-Activated Protein Kinase Kinase 4