Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MAP3K3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
MAP3K3 encodes MEKK3, a mitogen-activated protein kinase kinase kinase critical for NF-kB activation, stress response, and embryonic development.
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| Gene Symbol | MAP3K3 |
| Full Name | Mitogen-Activated Protein Kinase Kinase Kinase 3 |
| Chromosome | 17q23 |
| Protein Type | Kinase |
| Function | is a serine/threonine protein kinase that serves as a critical upstream activator of both the NF-κB and MAPK signaling pathways. |
| Subcellular Localization | The protein exists in an autoinhibited conformation in resting cells, with the kinase domain held in an inactive state b |
| Pathways | NF-κB, MAPK signaling, MAPK, NF-κB pathway |
| UniProt ID | [Q99731](https://www.uniprot.org/uniprot/Q99731) |
| Ensembl ID | ENSG00000106803 |
| OMIM | 603013 |
| GeneCards | MAP3K3 |
| Human Protein Atlas | MAP3K3 |
| Cytoplasmic | Majority in resting cells |
| Membrane-proximal | Associates with signaling complexes upon activation |
| Nuclear | Translocates for some transcriptional responses |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
MAP3K3["MAP3K3"]
neurodegeneration["neurodegeneration"]
MAP3K3 -->|"implicated_in"| neurodegeneration
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning MAP3K3 in their description or question text
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