Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MAP3K6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
MAP3K6 (MEKK6): MAP kinase kinase kinase activating p38 MAPK in stress responses and neurodegeneration
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| Gene Symbol | MAP3K6 |
| Full Name | Mitogen-Activated Protein Kinase Kinase Kinase 6 |
| Aliases | MEKK6 |
| Chromosome | 1p36.21 |
| Protein Type | Kinase |
| Function | is a serine/threonine protein kinase that functions as an upstream activator of the p38 MAPK signaling pathway[@matsumoto2005]. |
| Amino Acids | 372 aa |
| Pathways | MAPK signaling, MAPK, MAPK pathway, pathway: **Direct Phosphorylation Targets**: |
| UniProt ID | [O43283](https://www.uniprot.org/uniprot/O43283) |
| Ensembl ID | ENSG00000142733 |
| GeneCards | MAP3K6 |
| Human Protein Atlas | MAP3K6 |
| Oxidative stress | Reactive oxygen species (ROS) |
| Pro-inflammatory cytokines | TNF-α, IL-1β, IL-6 |
| Environmental stress | UV radiation, heat shock |
| Associated Diseases | Parkinson's disease, Alzheimer's disease |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
MAP3K6["MAP3K6"]
neurodegeneration["neurodegeneration"]
MAP3K6 -->|"implicated_in"| neurodegeneration
style MAP3K6 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning MAP3K6 in their description or question text
No additional research found