MAPK11

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAPK11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Page for MAPK11

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graph TD
    A["MAPK11<br/>(p38beta MAPK)"]
    B["Cellular Stress<br/>Stimuli"]
    C["MKK3/MKK6<br/>Kinases"]
    D["ATF2<br/>Transcription Factor"]
    E["CREB<br/>Transcription Factor"]
    F["Pro-inflammatory<br/>Cytokines"]
    G["Neuronal<br/>Apoptosis"]
    H["Synaptic<br/>Dysfunction"]
    I["Neurodegeneration"]
    J["Alzheimer's<br/>Disease"]
    K["Parkinson's<br/>Disease"]
    L["Losmapimod<br/>Inhibitor"]
    M["Oxidative<br/>Stress"]
    N["Tau<br/>Phosphorylation"]

    B -->|"activates"| C
    C -->|"phosphorylates"| A
    M -->|"activates"| A
    A -->|"phosphorylates"| D
    A -->|"phosphorylates"| E
    A -->|"promotes"| F
    A -->|"induces"| G
    A -->|"impairs"| H
    A -->|"phosphorylates"| N
    F -->|"contributes to"| I
    G -->|"leads to"| I
    H -->|"contributes to"| I
    N -->|"promotes"| I
    I -->|"manifests as"| J
    I -->|"manifests as"| K
    L -->|"inhibits"| A

    classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
    classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
    classDef regulatory fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px
    classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px
    classDef therapeutic fill:#1a3a2a,stroke:#81c784,stroke-width:2px

    class A central
    class F,G,H,I,M,N pathological
    class C,D,E regulatory
    class J,K disease
    class L therapeutic
    class B pathological

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