Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Stroke: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Stroke is a disease characterized by neurodegeneration research. Key relationships include: activates, associated with, therapeutic target. Associated with Aging, Als, Alzheimer. Connected to 1362 entities in the SciDEX knowledge graph.
| Prevalence | ~15 million strokes worldwide per year |
| Associated Genes | GBM, C1Q, C1QA, C1QC, SPI1, APOE, LRP8, LRP5 |
| KG Connections | 2038 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
Stroke["Stroke"] -->|"associated"| Complement["Complement"]
Stroke["Stroke"] -->|"activates"| Epigenetic["Epigenetic"]
Stroke["Stroke"] -->|"associated"| Lipid_Metabolism["Lipid Metabolism"]
Stroke["Stroke"] -->|"associated"| Wnt["Wnt"]
Stroke["Stroke"] -->|"activates"| Autophagy["Autophagy"]
Stroke["Stroke"] -->|"activates"| Proteasome["Proteasome"]
LETM1["LETM1"] -->|"therapeutic target"| Stroke["Stroke"]
MCU["MCU"] -->|"therapeutic target"| Stroke["Stroke"]
OVERVIEW["OVERVIEW"] -->|"therapeutic target"| Stroke["Stroke"]
HSPG2["HSPG2"] -->|"interacts"| Stroke["Stroke"]
style Stroke fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Neurodegeneration | associated_with | disease | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| Aging | associated_with | disease | 1.00 |
| Oxidative Stress | regulates | pathway | 1.00 |
| Apoptosis | regulates | pathway | 1.00 |
| Autophagy | therapeutic_target | pathway | 1.00 |
| Apoptosis | therapeutic_target | pathway | 1.00 |
| Oxidative Stress | therapeutic_target | pathway | 1.00 |
| Apoptosis | inhibits | pathway | 1.00 |
| Immune Response | activates | pathway | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Blood-Brain Barrier | therapeutic_target | pathway | 1.00 |
| Als | activates | disease | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| Inflammation | inhibits | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| Ischemia | therapeutic_target | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| Ischemia | inhibits | disease | 1.00 |
| Ischemia | activates | disease | 1.00 |
| Apoptosis | associated_with | pathway | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| Ferroptosis | therapeutic_target | pathway | 1.00 |
| Oxidative Stress | inhibits | pathway | 1.00 |
| Stem Cell | therapeutic_target | pathway | 1.00 |
| Atherosclerosis | associated_with | disease | 0.95 |
| Ischemia | associated_with | disease | 0.95 |
| Inflammation | treats | disease | 0.95 |
| Inflammation | implicated_in | disease | 0.95 |
| Als | causes | disease | 0.95 |
| Blood-Brain Barrier Disruption | causes | disease | 0.90 |
| Post-Stroke Depression | causes | disease | 0.90 |
| Cytoskeletal Protein Destruction | causes | mechanism | 0.90 |
| Lipid Metabolism | associated_with | pathway | 0.90 |
| Phagocytosis | activates | pathway | 0.90 |
| Cholesterol | activates | pathway | 0.90 |
| Mitophagy | activates | pathway | 0.90 |
| Blood-Brain Barrier | implicated_in | pathway | 0.90 |
| Differentiation | therapeutic_target | pathway | 0.90 |
| Depression | associated_with | disease | 0.85 |
| Inflammation | causes | disease | 0.85 |
| Type 2 Diabetes | activates | disease | 0.85 |
| Neurodegeneration | therapeutic_target | disease | 0.85 |
| Neurodegeneration | regulates | disease | 0.85 |
| Als | inhibits | disease | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| OVERVIEW | therapeutic_target | gene | 1.00 |
| BDNF | activates | gene | 1.00 |
| NRF2 | activates | gene | 1.00 |
| TNF | activates | gene | 1.00 |
| TNF | inhibits | gene | 1.00 |
| GENES | associated_with | gene | 1.00 |
| GENES | activates | gene | 1.00 |
| Cardiovascular | associated_with | disease | 1.00 |
| AKT | activates | gene | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| NEUROINFLAMMATION | regulates | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| TNF-Α | activates | gene | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| APOPTOSIS | regulates | gene | 1.00 |
| MICROGLIA | activates | gene | 1.00 |
| APOPTOSIS | therapeutic_target | gene | 1.00 |
| MITOPHAGY | activates | gene | 1.00 |
| CYTOKINES | inhibits | gene | 1.00 |
| APOPTOSIS | inhibits | gene | 1.00 |
| TNF-Α | inhibits | gene | 1.00 |
| BRAIN INJURY | activates | gene | 1.00 |
| APOPTOSIS | associated_with | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | therapeutic_target | gene | 1.00 |
| NEUROINFLAMMATION | therapeutic_target | gene | 1.00 |
| FERROPTOSIS | therapeutic_target | gene | 1.00 |
| OXIDATIVE STRESS | therapeutic_target | gene | 1.00 |
| INFLAMMATION | inhibits | gene | 1.00 |
| NEUROINFLAMMATION | inhibits | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | activates | gene | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| NEUROINFLAMMATION | activates | gene | 1.00 |
| PARKINSON'S DISEASE | associated_with | gene | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | gene | 1.00 |
| ASTROCYTES | activates | gene | 1.00 |
| AMYOTROPHIC LATERAL SCLEROSIS | associated_with | gene | 1.00 |
| BRAIN INJURY | associated_with | gene | 1.00 |
| MICROGLIA | regulates | gene | 1.00 |
| INFLAMMATION | associated_with | gene | 1.00 |
| NEUROINFLAMMATION | associated_with | gene | 1.00 |
| AGING | associated_with | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| BRAIN INJURY | therapeutic_target | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | associated_with | gene | 1.00 |
| STROKE | associated_with | gene | 1.00 |
| NEURODEGENERATION | associated_with | gene | 1.00 |
| STROKE | activates | gene | 1.00 |
| ALZHEIMER | activates | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-14 | 0 hypotheses
neuroinflammation | 2026-04-07 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||