Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MEKK3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
MAP3K3 - Mitogen-activated protein kinase kinase kinase 3, upstream regulator of NF-κB and MAPK signaling in neurodegeneration
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| Gene Symbol | MEKK3 |
| Aliases | MAP3K3 |
| Protein Family | MAP3K serine/threonine kinases |
| Protein Type | Kinase |
| Function | is a serine/threonine protein kinase that serves as a critical upstream regulator of both NF-κB and MAPK signaling pathways. |
| Subcellular Localization | The kinase domain adopts the typical bilobal structure seen in protein kinases, with ATP binding in the deep cleft betwe |
| Molecular Weight | 75.1 kDa |
| Pathways | NF-κB, MAPK signaling |
| UniProt ID | Q99731 |
| GeneCards | MEKK3 |
| Human Protein Atlas | MEKK3 |
| Kinase domain ( residues 1-300) | The catalytic domain with serine/threonine kinase activity |
| REG1 regulatory domain (300-400) | Autoinhibitory region that maintains basal state |
| Proline-rich regions (400-500) | Sites for SH3 domain-containing protein interactions |
| C-terminal domain (500-650) | Regulatory region controlling subcellular localization |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
MEKK3["MEKK3"]
neurodegeneration["neurodegeneration"]
MEKK3 -->|"implicated_in"| neurodegeneration
style MEKK3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning MEKK3 in their description or question text
No additional research found