gene

MGEA5

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about MGEA5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Gene profile: MGEA5 - O-GlcNAcase, the enzyme that removes O-GlcNAc from proteins, target for tauopathies

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🧬 Gene Info

Gene Symbol	MGEA5
Full Name	O-GlcNAcase (OGA)
Aliases	Gene profile: MGEA5
Chromosome	10q24.32
Function	MGEA5 encodes O-GlcNAcase (OGA), a glycoside hydrolase that catalyzes the removal of O-linked β-N-acetylglucosamine (O-GlcNAc) from serine and threonine residues on target proteins.
Subcellular Localization	the cytoplasm and nucleus, where it regulates O-GlcNAcylation of numerous nuclear and cytoplasmic proteins[@warner2015]
Molecular Weight	103 kDa
Amino Acids	917 aa
UniProt ID	Q9H3K2
GeneCards	MGEA5
Human Protein Atlas	MGEA5
Associated Diseases	Alzheimer's disease
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: MGEA5 — AlphaFold Q9H3K2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

LY3372689 (Oglemilide)

therapeutic · 2234 words

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MGEA5 — O-GlcNAcase (OGA)

gene · 1779 words

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Pathway Diagram

graph TD
    MGEA5["MGEA5"]
    neurodegeneration["neurodegeneration"]
    MGEA5 -->|"implicated_in"| neurodegeneration
    style MGEA5 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning MGEA5 in their description or question text

No additional research found