Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MIRO2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
MIRO2 is a protein involved in neurodegeneration research. Key relationships include: activates, therapeutic target, associated with. Associated with Ms. Connected to 10 entities in the SciDEX knowledge graph.
| Gene Symbol | MIRO2 |
| Full Name | MIRO2 |
| Chromosome | 16p13.3. |
| Protein Type | Gene |
| Function | encodes a tail-anchored outer-membrane GTPase. |
| Molecular Weight | 68 kDa |
| Amino Acids | 618 aa |
| Pathways | Mitochondrial-Derived Vesicle Biogenesis |
| NCBI Gene ID | Search NCBI |
| GeneCards | MIRO2 |
| Human Protein Atlas | MIRO2 |
| Associated Diseases | neurodegeneration |
| Interactions | MIRO1 |
| KG Connections | 12 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
MIRO2["<b>MIRO2</b>"]
Ms{"Ms"}
MIRO2 -->|"regulates"| Ms
MIRO2 -->|"therapeutic target"| Ms
MIRO2 -->|"activates"| Ms
MIRO1["MIRO1"]
MIRO2 -->|"associated with"| MIRO1
MIRO2 -->|"activates"| MIRO1
Immune_Response(["Immune Response"])
MIRO2 -->|"therapeutic target"| Immune_Response
SACS["SACS"]
MIRO2 -->|"associated with"| SACS
neurodegeneration["neurodegeneration"]
MIRO2 -->|"implicated in"| neurodegeneration
MIRO1 -->|"activates"| MIRO2
style MIRO2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| mitochondrial-derived vesicle biogenesis | drives | process | 0.95 |
| Mitochondrial-Derived Vesicle Biogenesis | activates | process | 0.95 |
| Mitochondrial-Derived Vesicle Biogenesis | promotes | process | 0.95 |
| Ms | regulates | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| MIRO1 | associated_with | gene | 0.60 |
| MIRO1 | activates | gene | 0.60 |
| SACS | associated_with | gene | 0.60 |
| Immune Response | therapeutic_target | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||