disease

Ms

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Ms: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5783Connections

3Hypotheses

30Analyses

50Outgoing

50Incoming

Summary

Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous system characterized by demyelination and axonal degeneration. MS affects approximately 2.8 million people worldwide. The disease is mediated by autoreactive T cells and B cells that attack myelin sheaths, leading to disrupted nerve signal transmission. Key pathological features include inflammatory lesions, blood-brain barrier breakdown, oligodendrocyte death, and progressive neurodegeneration.

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Disease Info

Associated Genes	CD2AP, HCN1, JUN, IDH1, IDH2, RASA1, EPHB4, AQP4
KG Connections	5499 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

therapeutic · 15794 words

→

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Pathway Diagram

graph TD
    ACTB["ACTB"] -->|"regulates"| Ms["Ms"]
    PPARA["PPARA"] -->|"regulates"| Ms["Ms"]
    CAT["CAT"] -->|"regulates"| Ms["Ms"]
    SQSTM1["SQSTM1"] -->|"regulates"| Ms["Ms"]
    style Ms fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (513)

Target	Relation	Type	Str
Lipid Metabolism	activates	pathway	0.60
Mtor	regulates	pathway	0.60
Lysosomal Degradation	activates	pathway	0.60
Autophagy	regulates	pathway	0.60
Synaptic Plasticity	regulates	pathway	0.60
Dna Methylation	therapeutic_target	pathway	0.60
Wnt	therapeutic_target	pathway	0.60
Glycolysis	activates	pathway	0.60
Epigenetic	regulates	pathway	0.60
Lipid Metabolism	regulates	pathway	0.60
Sphingolipid	regulates	pathway	0.60
Complement	regulates	pathway	0.60
Akt	interacts_with	pathway	0.60
Complement	activates	pathway	0.60
Complement	associated_with	pathway	0.60
Apoptosis	therapeutic_target	pathway	0.60
Akt	activates	pathway	0.60
Angiogenesis	activates	pathway	0.60
Apoptosis	regulates	pathway	0.60
Immune Response	inhibits	pathway	0.60
Innate Immunity	inhibits	pathway	0.60
Epigenetic	therapeutic_target	pathway	0.60
Autophagy	therapeutic_target	pathway	0.60
Er Stress	regulates	pathway	0.60
Apoptosis	interacts_with	pathway	0.60
Autophagy	interacts_with	pathway	0.60
Mitophagy	interacts_with	pathway	0.60
Mapk	interacts_with	pathway	0.60
Oxidative Phosphorylation	interacts_with	pathway	0.60
Pi3K	interacts_with	pathway	0.60
Wnt	interacts_with	pathway	0.60
Mtor	interacts_with	pathway	0.60
Innate Immunity	activates	pathway	0.60
Nf-Κb	activates	pathway	0.60
Exocytosis	therapeutic_target	pathway	0.60
Dna Methylation	contributes_to	pathway	0.60
Epigenetic	contributes_to	pathway	0.60
Epigenetic	activates	pathway	0.60
Blood-Brain Barrier	therapeutic_target	pathway	0.60
Mitochondrial Function	interacts_with	pathway	0.60
Glycolysis	interacts_with	pathway	0.60
Circadian Rhythm	interacts_with	pathway	0.60
Circadian Rhythm	regulates	pathway	0.60
Lipid Metabolism	contributes_to	pathway	0.60
Oxidative Stress	regulates	pathway	0.60
Sleep-Wake	regulates	pathway	0.60
Sleep-Wake	activates	pathway	0.60
Circadian Rhythm	biomarker_for	pathway	0.60
Cholesterol	expressed_in	pathway	0.60
Lipid Metabolism	expressed_in	pathway	0.60

Incoming (5270)

Source	Relation	Type	Str
ACTB	regulates	gene	0.65
PPARA	regulates	gene	0.65
CAT	regulates	gene	0.65
SQSTM1	regulates	gene	0.65
RPS6KB1	regulates	gene	0.65
RAB7A	regulates	gene	0.65
SREBF1	regulates	gene	0.65
EIF4EBP1	regulates	gene	0.65
CTSD	regulates	gene	0.65
PPARGC1A	regulates	gene	0.65
LRP2	regulates	gene	0.65
MAP1LC3B	regulates	gene	0.65
MYC	regulates	gene	0.65
MTOR	regulates	gene	0.65
PIK3C3	regulates	gene	0.65
EGFR	regulates	gene	0.65
PPARG	regulates	gene	0.65
LAMP1	regulates	gene	0.65
RUBCN	regulates	gene	0.65
RPS6	regulates	gene	0.65
BACE1	therapeutic_target	gene	0.65
DCX	interacts_with	gene	0.65
CDK5	interacts_with	gene	0.65
LIS1	interacts_with	gene	0.65
DAB1	interacts_with	gene	0.65
PAFAH1B1	interacts_with	gene	0.65
REST	inhibits	gene	0.65
CD2AP	associated_with	gene	0.65
JUN	regulates	gene	0.65
DAB1	regulates	gene	0.65
FYN	regulates	gene	0.65
SRC	regulates	gene	0.65
HCN1	associated_with	gene	0.65
JUN	inhibits	gene	0.65
HCN1	inhibits	gene	0.65
HCN4	inhibits	gene	0.65
HCN2	inhibits	gene	0.65
HCN1	expressed_in	gene	0.65
HCN1	activates	gene	0.65
HCN4	regulates	gene	0.65
HCN2	regulates	gene	0.65
JUN	therapeutic_target	gene	0.65
SLC16A2	therapeutic_target	gene	0.65
SLC16A1	therapeutic_target	gene	0.65
IDH1	therapeutic_target	gene	0.65
VEGFA	therapeutic_target	gene	0.65
MDM4	therapeutic_target	gene	0.65
APOB	therapeutic_target	gene	0.65
SF3B1	therapeutic_target	gene	0.65
MET	therapeutic_target	gene	0.65

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SGMS1-Driven Sphingomyelin Accumulation Impairs BACE1 Lysoso	0.542	neurodegeneration	What molecular mechanisms link elevated
Acid-Degradable LNP-Mediated Prenatal CRISPR Intervention fo	0.465	neurodegeneration	CRISPR-based therapeutic approaches for
Synthetic Biology Approach: Designer Mitochondrial Export Sy	0.358	neurodegeneration	Mitochondrial transfer between neurons a

Mentioning Analyses (30)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Integrating biocatalysis with continuous flow: current status, challenges, and f [PMID:40639553]	Bai J, Huang C, Liu Y, Zheng X, Liu J et	J Adv Res	2026
Engineering chimeric signaling proteins for microbial whole-cell biosensors: fro [PMID:40903364]	Özer Bergman G, Mecacci S, Martins Dos S	Trends Biotechnol	2026
MTAP Deletion in Oncogenesis: A Synthetic Lethality Scenario. [PMID:41512197]	Rodon J, Johnson ML, George B, Shah PA,	Cancer Res	2026
Engineering the Caenorhabditis elegans genome with a nested, self-excising selec [PMID:41557645]	Gibney TV, Pani AM	Genetics	2026
Design and synthesis of BAP-1 inhibitors. [PMID:41761813]	Zhang Z, Yang X	Pak J Pharm Sci	2026
Optimized bacterial expression of a synthetic BRIL antibody. [PMID:41842660]	Cooper BF, Isom GL	Acta Crystallogr F Struct Biol	2026
Chemogenetic Modulation of Luciferase Emission Color for Imaging and Sensing. [PMID:41941277]	Manirakiza H, Shpinov Y, Gontier A, El H	ACS Sens	2026
A Constrained Degron Tag Engineered to Enhance Auxin-Inducible Protein Degradati [PMID:41941339]	Han Z, Alkhadrawi A, Tofani S, Zhang W,	ACS Synth Biol	2026
Bacterial DNA methylases as novel molecular and synthetic biology tools: recent [PMID:40047928]	Flores-Fernández CN, O'Callaghan CA	Applied microbiology and biote	2025
Rational multienzyme architecture design with iMARS. [PMID:39855196]	Wang J, Ouyang X, Meng S, Zhao B, Liu L,	Cell	2025
ZLN005 Alleviates the Dopaminergic Degeneration via PGC-1α-Mediated Mitochondria [PMID:41400900]	["Kaur J", "Naqvi S"]	Molecular neurobiology	2025
A synthetic protein-level neural network in mammalian cells. [PMID:39666795]	Chen Z, Linton JM, Xia S, Fan X, Yu D, W	Science (New York, N.Y.)	2024
Synthetic biology-based bacterial extracellular vesicles displaying BMP-2 and CX [PMID:38576241]	Liu H, Song P, Zhang H, Zhou F, Ji N, Wa	Journal of extracellular vesic	2024
Unstructured polypeptides as a versatile drug delivery technology. [PMID:37075961]	["Ji Y", "Liu D", "Zhu H", "Bao L", "Cha	Acta biomaterialia	2023
Harlequin syndrome associated with thoracic epidural anaesthesia. [PMID:35118419]	Persson RM, Tellnes K, Hoven H, Haaverst	Anaesthesia reports	2022
CPEB alteration and aberrant transcriptome-polyadenylation lead to a treatable S [PMID:34586830]	Picó S, Parras A, Santos-Galindo M, Pose	Sci Transl Med	2021
Transmission dynamics of a linear vanA-plasmid during a nosocomial multiclonal o [PMID:34285270]	Fujiya Y, Harada T, Sugawara Y, Akeda Y,	Scientific reports	2021
High resolution spatiotemporal patterns of seawater temperatures across the Beli [PMID:33199700]	Helmuth B, Leichter JJ, Rotjan RD, Casti	Scientific data	2020
Fat cadherins in mouse models of degenerative ataxias. [PMID:31695130]	["Baron O", "Grieshober D", "Dias C", "F	Scientific reports	2019
Dexamethasone Inhibits Copper-Induced Alpha-Synuclein Aggregation by a Metalloth [PMID:29064068]	["McLeary F", "Rcom-H'cheo-Gauthier A",	Neurotoxicity research	2018

Ms

Understanding Entity Pages

Summary

Wiki Pages (20)

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Clinical Management Guide for CBS/PSP

Corticobasal Syndrome (CBS)

Novel Therapy Index

CBS/PSP Supplements Guide

Parthanatos in Neurodegeneration

Alpha-Synuclein Pathology

Therapeutics

NPM1 Gene

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

neuroinflammation

GRIA3 Gene

NRF2 Oxidative Stress Pathway

Microglial Cells — Cell Type Hierarchy

NTF4 Protein

TREM2 Mechanism Hub

HNRNPA2B1 Protein

CBS/PSP Clinical Trials Guide

CLCN10 — Chloride Voltage-Gated Channel 10

Pathway Diagram

Outgoing (513)

Incoming (5270)

Targeting Hypotheses (3)

Mentioning Analyses (30)

How does engineered C. butyricum cross the blood-brain barrier to directly bind

How does SYNGAP1, a 'synaptic' protein, function in pre-synaptic radial glia cel

What molecular mechanisms link elevated sphingomyelin synthase activity to incre

Why does PRKN-mediated mitophagy, typically protective, cause harmful mitochondr

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

How does pericyte senescence mechanistically promote glioma cell growth and inva

What are the molecular mechanisms by which GLP-1RAs provide neuroprotective effe

What molecular mechanisms determine whether reactive astrocytes adopt neurotoxic

What molecular mechanisms enable functional recovery and muscle re-innervation a

How do P/Q channel deficits paradoxically increase thalamic excitability despite

What molecular mechanisms drive neuron-to-glioma synapse formation in high-neura

How do the seven novel ALS genes function in animal models to cause neurodegener

What molecular mechanisms enable microglia to neutralize OxPC-mediated neurodege

What molecular mechanisms underlie Atremorine's dramatic dopamine enhancement in

How does PIKFYVE inhibition activate unconventional protein clearance via exocyt

How do B cells mechanistically orchestrate tolerance to AQP4 and prevent autoimm

What mechanisms explain how IDH1/IDH2 mutations with reduced enzymatic activity

Which tau PTMs are both disease-specific and druggable with selective small mole

What are the specific molecular mechanisms by which peripheral monocytes cross t

What determines the temporal transition from protective to pathological stress g

What are the molecular determinants that control directional mitochondrial trans

What specific gene expression signatures in aging mouse brain predict human AD v

Which neural cell types exhibit the most pronounced gene expression alterations

Which cell-type vulnerability signatures from SEA-AD single-cell data represent

Do migratory animals encode specific spatial locations epigenetically or rely on

Can circadian interventions selectively target microglia without affecting other

What evidence supports Cdk5 activation as THE primary cause of AD versus other e

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Related Papers (20)