Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Microglial Activation / DAM Signature: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| TREM2 | participates_in | gene | 0.73 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Cell-Type Specific TREM2 Upregulation in DAM Microglia | 0.519 | Alzheimer's Disease | SEA-AD Gene Expression Profiling — Allen |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-02 | 5 hypotheses Top: 0.519
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797] | Zhou Y, Song WM, Andhey PS, Swain A, Lev | Nat Med | 2020 | 1 |
| Moderate Effects of the Arginine to Histidine R47H Variant of the Triggering Rec [PMID:41890852] | ["Ramirez G", "Hernandez D", "Teal A", " | Research square | 2026 | 0 |
| Increased plasma soluble TREM2 levels in non-Alzheimer's dementia. [PMID:41920402] | Güven G, Gezegen H, Şahin E, Samancı B, | Acta neurologica Belgica | 2026 | 0 |
| AI-guided design of cyclic peptide binders targeting TREM2 using CycleRFdiffusio [PMID:41435973] | Cho S, Zhu R, Kuncewicz K, Duan H, Gabr | Bioorg Med Chem Lett | 2026 | 0 |
| ITAM-Syk signaling mediates the rebound phenomenon after anti-RANKL antibody dis [PMID:41490759] | Ishizu H, Hasegawa T, Shimizu T, Yamamot | Bone | 2026 | 0 |
| Oxaliplatin-artesunate conjugate intensifies suppression on colorectal cancer by [PMID:41520444] | Tan Y, Yang T, Jiang S, Li S, Cai L et a | J Inorg Biochem | 2026 | 0 |
| Diankuang Mengxing Decoction exerts neuroprotective effects in post-stroke depre [PMID:41534750] | Yang X, Zhao Y, Liu W, Feng J, Wu X et a | J Ethnopharmacol | 2026 | 0 |
| Loss of Triggering Receptor Expressed on Myeloid Cells 2 Impairs Microglial Func [PMID:41643896] | Chen G, Wang Z, Zhao C, Wang C, Li Y et | Am J Pathol | 2026 | 0 |
| Microglial metabolic reprogramming in Alzheimer's disease: Pathways, mechanisms, [PMID:41651180] | Yang FG, Yang H, Han SW, Wang JT, Gao W | Ageing Res Rev | 2026 | 0 |
| Plant-derived bioactive compounds modulate the gut microbiota in Alzheimer's dis [PMID:41678917] | Xue D, Hu X, Li R, Sun T, Qian S et al. | Phytomedicine | 2026 | 0 |
| Triggering Receptor Expressed on Myeloid Cells-2 Regulates Innate Lymphoid Cell [PMID:41928407] | Shen HC, Chen NJ, Sun CY, Yu WK, Su VY e | Kaohsiung J Med Sci | 2026 | 0 |
| TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, le [PMID:41930604] | Yang HC, Deng YS, Zhang J, Zhang T, Song | J Alzheimers Dis | 2026 | 0 |
| Hierarchical Targeting of TREM2(+) Myeloid Cells via Acid-Triggered OMVs Reprogr [PMID:41945876] | Chen F, Xue Y, Ma X, Chen L, Shao Z et a | Adv Sci (Weinh) | 2026 | 0 |
| Correction to "A Strategy Involving Microporous Microneedles Integrated with CAR [PMID:41952643] | Unknown | Advanced materials (Deerfield | 2026 | 0 |
| Glycoursodeoxycholic acid regulates peritoneal monocytic myeloid-derived suppres [PMID:41955910] | Wang R, Wang B, Li B, Zhang J, Li Y et a | J Autoimmun | 2026 | 0 |
| A scalable human-zebrafish xenotransplantation model reveals gastrosome-mediated [PMID:41957412] | Villani A, Wittmann J, Wyss T, Mallona I | Commun Biol | 2026 | 0 |
| Dual Role of Microglial TREM2 in Neuronal Degeneration and Regeneration After Ax [PMID:41963086] | Pottorf TS, Lane EL, Haley-Johnson Z, Uk | J Neurosci | 2026 | 0 |
| TREM2-mediated microglial phagocytosis of inhibitory synapses contributes to pro [PMID:41965330] | Wang X, Zhou H, Zhai Y, Zhang Y, Cheng Y | Cell Death Discov | 2026 | 0 |
| Population-scale burden analysis of rare damaging coding variants identifies nov [PMID:41867223] | Le Guen Y, Peña-Tauber A, Pulgrossi RC, | medRxiv : the preprint server | 2026 | 0 |
| TREM2 as a possible link between Alzheimer's disease and diabetes mellitus. [PMID:41862118] | Chen W, Huang N, Huang W, Wang M, Luo Y, | Experimental neurology | 2026 | 0 |