Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NAPA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NAPA encodes alpha-SNAP, essential for SNARE complex disassembly and synaptic vesicle recycling
| Gene Symbol | NAPA |
| Full Name | NSF Attachment Protein Alpha |
| Chromosome | 19q13.33 |
| Function | is a 295 amino acid protein that functions as an adaptor between NSF (N-ethylmaleimide-sensitive fusion protein) and SNARE complexes. |
| Primary Expression | the nervous system[@liu2012]: |
| Amino Acids | 295 aa |
| UniProt ID | P54920 |
| NCBI Gene ID | 8775 |
| Ensembl ID | ENSG00000101190 |
| OMIM | 162605 |
| GeneCards | NAPA |
| Human Protein Atlas | NAPA |
| Vesicle priming | SNARE complexes form and are primed for fusion |
| Fusion | Synaptic vesicles fuse with the presynaptic membrane |
| alpha-SNAP recruitment | After fusion, alpha-SNAP binds to the used SNAREs |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
NAPA["NAPA"]
neurodegeneration["neurodegeneration"]
NAPA -->|"implicated_in"| neurodegeneration
style NAPA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||