Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NEU1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | NEU1 |
| Function | NEU1 encodes neuraminidase 1, also known as sialidase 1, a lysosomal enzyme that cleaves terminal sialic acid residues from glycoproteins, glycolipids, and oligosaccharides. |
| Primary Expression | neurons throughout the cortex, hippocampus, basal ganglia, and cerebellum |
| Subcellular Localization | and stability in the lysosome |
| Ensembl ID | ENSG00000105694 |
| GeneCards | NEU1 |
| Human Protein Atlas | NEU1 |
| Glycoprotein degradation | Cleaving sialic acid residues to expose underlying sugars for further hydrolysis |
| Lysosomal function | Essential for proper lysosomal enzyme activity and autophagy |
| Cell surface remodeling | Modifying glycoconjugates on the cell surface |
| Immune regulation | Influencing immune cell function through modification of surface receptors |
| Liver | Highest expression |
| Brain | Neurons, astrocytes, microglia |
| Kidney | Tubular epithelial cells |
| Associated Diseases | neurodegeneration |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
NEU1["NEU1"]
Als["Als"]
AIF1["AIF1"]
HSPA1A["HSPA1A"]
neurodegeneration["neurodegeneration"]
NEU1 -->|"therapeutic target"| Als
NEU1 -->|"associated with"| AIF1
HSPA1A -->|"associated with"| NEU1
NEU1 -->|"implicated in"| neurodegeneration
style NEU1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
style Als fill:#3e1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
style AIF1 fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
style HSPA1A fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
style neurodegeneration fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| Als | therapeutic_target | disease | 0.65 |
| AIF1 | associated_with | gene | 0.60 |
| benchmark_ot_ad_answer_key:NEU1 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
| HSPA1A | associated_with | gene | 0.60 |
| benchmark_ot_ad_answer_key:NEU1 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||