gene

AIF1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AIF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

377Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

AIF1 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, activates, associated with. Associated with ALS, Aging, Als. Connected to 142 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	AIF1
Function	encodes a calcium-binding cytoskeletal adaptor that is strongly enriched in microglia.
Pathways	Autophagy, Inflammasome, Mitophagy, Neuroinflammatory
Ensembl ID	ENSG00000240065
GeneCards	AIF1
Human Protein Atlas	AIF1
Associated Diseases	ALS, Aging, Alzheimer
Known Drugs/Compounds	rapamycin
Interactions	ASC, NLRP3, SQSTM1, TNF, PYCARD, MAP1LC3B
KG Connections	377 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    AIF1["AIF1"] -.->|"inhibits"| Neurodegeneration["Neurodegeneration"]
    AIF1["AIF1"] -.->|"inhibits"| Inflammation["Inflammation"]
    AIF1["AIF1"] -.->|"inhibits"| Als["Als"]
    AIF1["AIF1"] -.->|"inhibits"| Aging["Aging"]
    AIF1["AIF1"] -.->|"inhibits"| Tumor["Tumor"]
    AIF1["AIF1"] -.->|"inhibits"| Parkinson["Parkinson"]
    CKLF["CKLF"] -->|"contributes to"| AIF1["AIF1"]
    ACTB["ACTB"] -->|"associated"| AIF1["AIF1"]
    IL1B["IL1B"] -.->|"inhibits"| AIF1["AIF1"]
    IL6["IL6"] -.->|"inhibits"| AIF1["AIF1"]
    style AIF1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (287)

Target	Relation	Type	Str
MICROGLIA	expressed_in	cell_type	0.90
Microglial Activation	biomarker_for	process	0.85
NRF2	co_discussed	gene	0.65
neurodegeneration	co_discussed	concept	0.65
neuroinflammation	co_discussed	concept	0.65
Neurodegeneration	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Als	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Parkinson	inhibits	disease	0.65
Inflammation	activates	disease	0.65
Als	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Ms	activates	disease	0.65
Als	therapeutic_target	disease	0.65
ALS	inhibits	disease	0.65
Alzheimer	associated_with	disease	0.65
DOPAMINERGIC	associated_with	cell_type	0.65
NEURON	associated_with	cell_type	0.65
NEURONS	associated_with	cell_type	0.65
TNF-ALPHA	regulates	gene	0.65
ALS	activates	disease	0.65
Als	associated_with	disease	0.65
Aging	associated_with	disease	0.65
ALS	associated_with	disease	0.65
ATG7	associated_with	gene	0.60
ASC	inhibits	gene	0.60
NLRP3	inhibits	gene	0.60
GAPDH	associated_with	gene	0.60
SQSTM1	inhibits	gene	0.60
TNF	inhibits	gene	0.60
PYCARD	inhibits	gene	0.60
MAP1LC3B	inhibits	gene	0.60
GFAP	associated_with	gene	0.60
ACTB	associated_with	gene	0.60
BECN1	activates	gene	0.60
ATG5	associated_with	gene	0.60
PTEN	activates	gene	0.60
PRKN	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
DNM1L	activates	gene	0.60
OPTN	activates	gene	0.60
SQSTM1	activates	gene	0.60
PINK1	activates	gene	0.60
ATG5	co_discussed	gene	0.60
ATG7	co_discussed	gene	0.60
BECN1	co_discussed	gene	0.60
CASP1	co_discussed	gene	0.60
GFAP	co_discussed	gene	0.60

Incoming (90)

Source	Relation	Type	Str
CKLF	contributes_to	protein	0.80
ACTB	associated_with	gene	0.60
IL1B	inhibits	gene	0.60
IL6	inhibits	gene	0.60
CASP1	associated_with	gene	0.60
ATG5	associated_with	gene	0.60
GFAP	associated_with	gene	0.60
SNCA	inhibits	gene	0.60
BECN1	associated_with	gene	0.60
SQSTM1	inhibits	gene	0.60
TNF	inhibits	gene	0.60
MAP1LC3B	inhibits	gene	0.60
NLRP3	inhibits	gene	0.60
ATG7	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
PYCARD	inhibits	gene	0.60
ASC	inhibits	gene	0.60
DNM1L	activates	gene	0.60
SQSTM1	activates	gene	0.60
PTEN	activates	gene	0.60
OPTN	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
PINK1	activates	gene	0.60
PRKN	activates	gene	0.60
BECN1	activates	gene	0.60
HSPA1A	therapeutic_target	gene	0.60
NEU1	associated_with	gene	0.60
UBIQUITIN	inhibits	gene	0.60
IBA1	associated_with	gene	0.60
APP	associated_with	gene	0.60
C1QB	biomarker_for	gene	0.60
TMEM119	biomarker_for	gene	0.60
CCR1	associated_with	gene	0.60
C1QB	associated_with	gene	0.60
CD4	associated_with	gene	0.60
ITGAM	biomarker_for	gene	0.60
C1QC	biomarker_for	gene	0.60
TYROBP	associated_with	gene	0.60
C1QA	biomarker_for	gene	0.60
CD68	biomarker_for	gene	0.60
C4B	biomarker_for	gene	0.60
TREM2	biomarker_for	gene	0.60
CYBB	biomarker_for	gene	0.60
CYBB	associated_with	gene	0.60
CD163	associated_with	gene	0.60
CSF1R	associated_with	gene	0.60
C3AR1	associated_with	gene	0.60
C1QA	associated_with	gene	0.60
ACTB	regulates	gene	0.60
ADAM10	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

AIF1

Understanding Entity Pages

Summary

Wiki Pages (21)

AIF1 Gene

Microglial Cells — Cell Type Hierarchy

Neuroinflammation Microglia

Microglia

SPI1 Gene - PU.1

iPSC-Derived Microglia

CCR1

CBS Epigenetic Mechanisms

CASP1 Gene

CBS Single-Cell Transcriptomics Mechanisms

Inferotemporal Cortex

RNA Binding Fox-3 Homolog (NeuN) (RBFOX3)

Transdiagnostic Proteomic Changes in Neurodegeneration

Synaptic Pruning Microglia

Surveying Microglia

Lateral Prefrontal Cortex

CD4 Gene

IBA1 Protein

Arcuate Nucleus Neurons