protein

HSPA1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSPA1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

955Connections

2Hypotheses

4Analyses

50Outgoing

50Incoming

9Experiments

5Debates

Summary

HSPA1A is a protein involved in neurodegeneration research. Key relationships include: associated with, activates, expressed in. Associated with AD, ALI, ALS. Connected to 518 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	HSPA1A
Full Name	Heat Shock 70 kDa Protein 1A (Hsp70-1A)
Aliases	HSP70-1A, HSP70, Hsp70
Protein Family	Hsp70 family
Protein Type	Chaperone
Target Class	Chaperone
Function	Small molecule activators or allosteric modulators of chaperone function
Mechanism of Action	Small molecule activators or allosteric modulators of chaperone function
Subcellular Localization	Cytoplasm, Nucleus, Cell membrane
Druggability	Medium (0.46)
Clinical Stage	Phase III
Molecular Weight	~70 kDa
Pathways	Akt, Chaperone, ERK/JNK Pathway, Erk/Jnk Pathway, Lipid Metabolism
UniProt ID	P0DMV8
GeneCards	HSPA1A
Human Protein Atlas	HSPA1A
Associated Diseases	AD, AGE_RELATED_DISEASES, Aging, ALI, Als
Known Drugs/Compounds	KNK437, RN5S, Trna
Interactions	ACSL4, ager, AGER, AGING, ALOX15, ALS
SciDEX Target	View Target Profile (6 clinical trials)
SciDEX Hypotheses	Proteostasis Enhancement via APOE Chaperone Target Heat Shock Protein 70 Disaggregase Amplification
KG Connections	942 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🧬 3D Structure Comparison — HSPA1A Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

3UPV — X-ray / Cryo-EM

🔮 AI Predicted Structure

P0DMV8 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    HSPA1A(["HSPA1A"])
    Reactive_Oxygen_Species["Reactive Oxygen Species"]
    Prostatic_Epithelium["Prostatic Epithelium"]
    ERK_JNK_Pathway["ERK/JNK Pathway"]
    Traumatic_Spinal_Cord_Injury["Traumatic Spinal Cord Injury"]
    Functional_Recovery("Functional Recovery")
    Oligodendrocytes["Oligodendrocytes"]
    HELLP_Syndrome["HELLP Syndrome"]
    h_5dbfd3aa["h-5dbfd3aa"]
    h_637a53c9["h-637a53c9"]
    h_74777459["h-74777459"]
    Benign_Prostatic_Hyperplasia["Benign Prostatic Hyperplasia"]
    Cell_Proliferation("Cell Proliferation")

    HSPA1A -.->|"inhibits"| Reactive_Oxygen_Species
    HSPA1A -->|"expressed in"| Prostatic_Epithelium
    HSPA1A -->|"regulates"| ERK_JNK_Pathway
    HSPA1A -->|"protects against"| Traumatic_Spinal_Cord_Injury
    HSPA1A -->|"associated with"| Functional_Recovery
    HSPA1A -->|"expressed in"| Oligodendrocytes
    HSPA1A -->|"biomarker for"| HELLP_Syndrome
    h_5dbfd3aa -->|"therapeutic target"| HSPA1A
    h_637a53c9 -->|"therapeutic target"| HSPA1A
    h_74777459 -->|"therapeutic target"| HSPA1A
    h_5dbfd3aa -->|"targets gene"| HSPA1A
    h_637a53c9 -->|"targets gene"| HSPA1A
    h_74777459 -->|"targets gene"| HSPA1A
    HSPA1A -->|"biomarker for"| Benign_Prostatic_Hyperplasia
    HSPA1A -->|"regulates"| Cell_Proliferation

    style HSPA1A fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (593)

Target	Relation	Type	Str
RN5S	binds	compound	0.95
Trna	binds	compound	0.95
Benign Prostatic Hyperplasia	associated_with	disease	0.95
Erk/Jnk Pathway	regulates	pathway	0.95
Benign Prostatic Hyperplasia	involved_in	disease	0.95
Trna Gene Transcription	activates	process	0.92
Non-Coding Rna Biogenesis	involved_in	process	0.92
Prostatic Epithelium	expressed_in	cell_type	0.92
ERK/JNK Pathway	regulates	pathway	0.90
Therapeutic Target	targets	mechanism	0.90
Benign Prostatic Hyperplasia	implicated_in	disease	0.90
reactive oxygen species	suppresses	compound	0.90
Spinal Cord Injury	protects_against	disease	0.90
Erk/Jnk Pathway	modulates	pathway	0.90
Benign Prostatic Hyperplasia	upregulates	disease	0.90
HELLP Syndrome	biomarker_for	disease	0.90
Rna Polymerase Iii	regulates	enzyme	0.90
Hellp Syndrome	associated_with	disease	0.90
Traumatic Spinal Cord Injury	protects_against	disease	0.90
Cellular Homeostasis	associated_with	process	0.90
Benign Prostatic Hyperplasia	contributes_to	disease	0.90
Oligodendrocytes	expressed_in	cell_type	0.90
Functional Recovery	associated_with	phenotype	0.90
Benign Prostatic Hyperplasia	biomarker_for	disease	0.88
Cell Proliferation	regulates	process	0.88
sleep disorders	therapeutic_target	disease	0.88
Hepatocellular Injury	associated_with	process	0.85
ERK/JNK pathway	modulates	pathway	0.85
Protein Homeostasis	involved_in	process	0.85
Immunological Tolerance	associated_with	process	0.85
Preeclampsia	biomarker_for	disease	0.85
Age-Related Diseases	biomarker_for	disease	0.85
Apoptosis	suppresses	process	0.85
Parkinson's Disease	upregulates	disease	0.85
Multiple Sclerosis	upregulates	disease	0.85
Sleep	regulates	process	0.85
Preterm Delivery	risk_factor_for	disease	0.85
Alzheimer's Disease	upregulates	disease	0.85
Normal Pregnancy	downregulates	phenotype	0.85
Prostatic Stroma	expressed_in	cell_type	0.85
Prostate Volume	correlates_with	phenotype	0.85
KNK437	targets	drug	0.85
DUSP1	upregulates	protein	0.85
Apoptosis	involved_in	process	0.85
ERK/JNK pathway	activates	pathway	0.80
Apoptosis	regulates	process	0.80
BPH-1 cells	associated_with	cell_type	0.80
ERK/JNK pathway	associated_with	pathway	0.80
Immune Response	elicits	process	0.80
Maternal Immune Tolerance	promotes	process	0.80

Incoming (362)

Source	Relation	Type	Str
h-637a53c9	targets_gene	hypothesis	0.90
h-74777459	targets_gene	hypothesis	0.90
h-5dbfd3aa	targets_gene	hypothesis	0.90
h-5d943bfc	targets_gene	hypothesis	0.90
ERK1/2	interacts_with	gene	0.90
Testosterone-Induced BPH	upregulates	phenotype	0.85
TFE3	regulates	gene	0.80
HSP90AA1	regulates	protein	0.80
h-5dbfd3aa	targets	hypothesis	0.80
Necrotic Cells	associated_with	cell_type	0.80
h-74777459	targets	hypothesis	0.80
h-637a53c9	targets	hypothesis	0.80
Sleep	regulates	process	0.75
TP53	regulates	entity	0.70
ATP	interacts_with	gene	0.65
HSP40	activates	gene	0.65
ERK	treats	gene	0.65
KNK437	inhibits	drug	0.64
DNAJB1	interacts_with	gene	0.61
FKBP5	interacts_with	gene	0.61
HSP90AA1	interacts_with	gene	0.61
NF-ΚB	interacts_with	gene	0.60
CAPZB	therapeutic_target	gene	0.60
RAB5A	therapeutic_target	gene	0.60
AGER	interacts_with	gene	0.60
AGER	binds_to	gene	0.60
ZFP36	therapeutic_target	gene	0.60
IL-6	therapeutic_target	gene	0.60
MIRNAS	associated_with	gene	0.60
CANCER	inhibits	gene	0.60
CANCER	interacts_with	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
CANCER	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
NF-ΚB	expressed_in	gene	0.60
PHAGOCYTOSIS	expressed_in	gene	0.60
ROS	activates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
SLC3A2	regulates	gene	0.60
CANCER	biomarker_for	gene	0.60
HSPA1B	associated_with	gene	0.60
AGER	associated_with	gene	0.60
CEBPA	therapeutic_target	gene	0.60
CSF2	regulates	gene	0.60
NAMPT	regulates	gene	0.60
FGF2	regulates	gene	0.60
CXCL10	regulates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Proteostasis Enhancement via APOE Chaperone Targeting	0.724	neurodegeneration	Mechanistic role of APOE in neurodegener
Heat Shock Protein 70 Disaggregase Amplification	0.668	neurodegeneration	TDP-43 phase separation therapeutics for

Mentioning Analyses (4)

Scientific analyses that reference this entity

Experiments (9)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
s:** - Dose-response studies showing therapeutic window without toxici	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
Chaperone-Mediated Autophagy Dysfunction in PD - Experiment Design	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Mutant Huntingtin (mHTT) Clearance Mechanisms — Therapeutic Target Val	validation	Neurodegeneration	0.400	0.50	human	proposed	$3,000,000
Multiscale Computational Modeling of Protein Aggregation Kinetics	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,280,000
Prion Strain Diversity and Selective Vulnerability in CJD	clinical	Neurodegeneration	0.400	0.50	human	proposed	$5,460,000
Proteasome-Ubiquitin System Dysfunction Validation in Parkinson's Dise	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Protein Aggregation Kinetic Validation Results	validation	Neurodegeneration	0.400	0.50	in_silico	proposed	$120,000
Experiment Validation: In vitro ThT Assay	validation	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$160,000
Viral Infections and Alzheimer's Disease — causal mechanisms and thera	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Heat Shock Protein Family A Member 1A Attenuates Apoptosis and Oxidative Stress [PMID:40066224]	Liu H, Zhou Y, Wang Z, Liu D, Li Y, Lai	MedComm (2020)	2025	1
From sleep to cancer to neurodegenerative disease: the crucial role of Hsp70 in [PMID:37643058]	Ghosh S, Vashisth K, Ghosh S, Han SS, Bh	J Biomol Struct Dyn	2024	1
Plasma proteins and onset of type 2 diabetes and diabetic complications: Proteom [PMID:37652020]	Yuan S, Xu F, Li X, Chen J, Zheng J, Man	Cell Rep Med	2023	1
Circulating heat shock protein 70 (HSPA1A) in normal and pathological pregnancie [PMID:19821156]	Molvarec A, Tamási L, Losonczy G, Madách	Cell Stress Chaperones	2010	1
Integrating NHANES and network toxicology to assess the impact of organophosphat [PMID:41804832]	Dai K, Huang Y, Cai H, Zhong G, Xie Z, W	Toxicology mechanisms and meth	2026	0
Crystal structures reveal phosphorylation-dependent disruption of the heat shock [PMID:41833837]	Stewart M, Paththamperuma C, McCann C, C	Cell stress & chaperones	2026	0
Aryl hydrocarbon receptor-mediated transcriptional regulation of HSP70 exacerbat [PMID:41725010]	Wen M, Li J, Li Y, Hun M, Yang T, Meng Y	Cell & bioscience	2026	0
Guhan Yangsheng Jing alleviates sleep deprivation-induced neuronal injury via ne [PMID:41539636]	["Fu X", "Long Q", "Wang Z", "Yan S", "L	Journal of ethnopharmacology	2026	0
Single-cell transcriptomics reveal heat shock protein dysregulation in severe SA [PMID:41772029]	Suzuki T, Sato Y, Suzuki M, Fukuda Y, Iw	Scientific reports	2026	0
Heat shock suppresses the innate immune response of bovine endometrial epithelia [PMID:41665179]	Tariq A, Sagheer M, Seekford ZK, Ren J,	Reproduction & fertility	2026	0
Single nucleus RNA sequencing profile analysis to reveal cell type specific comm [PMID:40715263]	Pappu MAA, Alamin M, Sultana MH	Sci Rep	2025	0
Downregulation of NEAT1 due to loss of TDP-43 function exacerbates motor neuron [PMID:40661327]	Kawakami Y, Iguchi Y, Li J	Brain Commun	2025	0
Echocardiography Versus Magnetic Resonance Imaging Quantification and Novel Algo [PMID:37890567]	["Wang T", "Reyaldeen R", "Akyuz K", "Po	The American journal of cardio	2024	0
Integrating network pharmacology and drug side-effect data to explore mechanism [PMID:38308871]	["Tang M", "Wu Z", "Li F"]	Computers in biology and medic	2024	0
Novel genetic insight for psoriasis: integrative genome-wide analyses in 863 080 [PMID:39883516]	Liu S, Li L, Liang Y, Tan Y, Wang X, Fen	Briefings in bioinformatics	2024	0
Lactate is an epigenetic metabolite that drives survival in model systems of gli [PMID:35948010]	Torrini C, Nguyen TTT, Shu C, Mela A, Hu	Molecular cell	2022	0
Is targeting angiotensin-converting enzyme 2 (ACE2) a prophylactic strategy agai [PMID:36567123]	["Li J", "Yan Y", "Dou F", "Gao J"]	Bioscience trends	2022	0
Proximity proteomics of C9orf72 dipeptide repeat proteins identifies molecular c [PMID:35164882]	["Liu F", "Morderer D", "Wren M", "Vettl	Acta neuropathologica communic	2022	0
Salmon aquaculture threatens Patagonia. [PMID:33986174]	["Juan G Navedo", "Luis Vargas-Chacoff"]	Science (New York, N.Y.)	2021	0
Re-identification of individuals in genomic datasets using public face images. [PMID:34788101]	Venkatesaramani R, Malin BA, Vorobeychik	Science advances	2021	0

Debates (5)

Multi-agent debates referencing this entity

HSPA1A

Understanding Entity Pages

Summary

Wiki Pages (4)

HSPA1A Gene

HSP70 (Heat Shock Protein 70 / HSPA1A)

Heat Shock Protein 70 (HSPA1A)

HSPA1A Protein

Pathway Diagram

Outgoing (593)

Incoming (362)

Targeting Hypotheses (2)

Mentioning Analyses (4)

APOE4 structural biology and therapeutic targeting strategies

TDP-43 phase separation therapeutics for ALS-FTD

Mechanistic role of APOE in neurodegeneration

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

Experiments (9)

Related Papers (20)

Debates (5)

TDP-43 undergoes liquid-liquid phase separation that becomes pathological. Small

TDP-43 phase separation therapeutics for ALS-FTD

APOE4 differs from APOE3 by C112R causing domain interaction that alters lipid b

Analysis question not specified

What are the mechanisms underlying what are the mechanisms by which gut microbio