Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Inflammasome Complex: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
A multi-protein complex that activates caspase-1-mediated inflammatory responses. The NLRP3 inflammasome is the best-characterized, consisting of NLRP3 sensor, ASC adaptor (PYCARD), and pro-caspase-1. Assembly triggers IL-1β and IL-18 maturation and pyroptotic cell death. NLRP3 inflammasome activation is driven by amyloid-β, α-synuclein, and tau aggregates in neurodegenerative diseases.
Ontology: GO:0061702 · MESH:D000077192
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| Name | NLRP3_INFLAMMASOME |
| Key Genes/Proteins | IL18, IL1B, TREM2 |
| Related Diseases | microglial_activation |
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| microglial_activation | activates | phenotype | 0.70 |
| IL1B | produces | protein | 0.64 |
| IL18 | produces | protein | 0.64 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TREM2 | inhibits | protein | 0.72 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 19 hypotheses Top: 0.891
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Interaction between autophagy and the NLRP3 inflammasome in Alzheimer's and Park [PMID:36262883] | Unknown | Frontiers in aging neuroscienc | 2023 | 0 |
| Inhibition of autophagy in microglia and macrophages exacerbates innate immune r [PMID:36652438] | Hegdekar N, Sarkar C, Bustos S, Ritzel R | Autophagy | 2023 | 0 |
| Parkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's [PMID:37029500] | Yan YQ, Zheng R, Liu Y, Ruan Y, Lin ZH, | Aging cell | 2023 | 0 |
| Microglial NLRP3 inflammasome activates neurotoxic astrocytes in depression-like [PMID:36288697] | Li S, Fang Y, Zhang Y, Song M, Zhang X, | Cell reports | 2022 | 0 |
| Biomarker of Neuroinflammation in Parkinson's Disease. [PMID:35456966] | Liu TW, Chen CM, Chang KH | Int J Mol Sci | 2022 | 0 |
| NLRP3 inflammasome activation drives tau pathology. [PMID:31748742] | ["Ising C", "Venegas C", "Zhang S", "Sch | Nature | 2019 | 0 |
| Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodeg [PMID:30381407] | Gordon R, Albornoz EA, Christie DC, Lang | Science translational medicine | 2018 | 0 |
| NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS [PMID:23254930] | Heneka MT, Kummer MP, Stutz A, Delekate | Nature | 2013 | 0 |
| NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS [PMID:23254930] | ["Heneka Michael T", "Kummer Markus P", | Nature | 2013 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.57 · 2026-04-28
closed · Rounds: 4 · Score: 0.12 · 2026-04-27
closed · Rounds: 4 · Score: 0.42 · 2026-04-27
closed · Rounds: 4 · Score: 0.48 · 2026-04-27
closed · Rounds: 4 · Score: 0.47 · 2026-04-27
closed · Rounds: 4 · Score: 0.52 · 2026-04-27
closed · Rounds: 4 · Score: 0.72 · 2026-04-27
closed · Rounds: 4 · Score: 0.90 · 2026-04-03
Hypotheses and analyses mentioning Inflammasome Complex in their description or question text
Score: 0.625 · neuroscience · 2026-04-22
**Molecular Mechanism and Rationale** Galectin-3 (LGALS3) functions as a critical molecular sensor and platform orchest
Score: 0.620 · neurodegeneration · 2026-04-26
Gut-derived bacterial components (LPS, MDP) provide Signal 1 for NLRP3 inflammasome priming via TLR4/TLR2/NOD2, inducing
Score: 0.620 · neuroscience · 2026-04-22
## Mechanistic Overview Selective cathepsin B inhibition prevents cathepsin leakage-mediated NLRP3 inflammasome activati
Score: 0.610 · neurodegeneration · 2026-04-28
NLRP3 inflammasome activation releases IL-1β, driving complement cascade upregulation and synapse elimination. MCC950 or
Score: 0.590 · neurodegeneration · 2026-04-25
This hypothesis proposes that HBOT reduces ROS-mediated NF-κB activation and NLRP3 inflammasome assembly, promoting anti
Score: 0.566 · developmental-neurobiology · 2026-04-21
## Mechanistic Overview NLRP3 Inflammasome Chromatin Priming Through H3K27ac Accumulation starts from the claim that mod
Score: 0.566 · neurodegeneration · 2026-04-16
## Mechanistic Overview NLRP3 Inflammasome Blockade as Upstream Intervention to Prevent SASP Amplification starts from t
Score: 0.563 · biomarkers · 2026-04-22
## Mechanistic Overview P2X7R PET Imaging for NLRP3 Inflammasome-Associated Priming starts from the claim that modulatin
Score: 0.485 · neuroinflammation · 2026-04-21
## Mechanistic Overview TFEB-Mediated Lysosomal Biogenesis Enhancement for NLRP3 Inflammasome Regulation starts from the
Score: 0.465 · unknown disease · 2026-04-26
Trazodone acts as a weak antagonist at P2X7 purinergic receptors (IC50 ~3 micromolar), suppressing microglial NLRP3 infl
Score: 0.380 · neuroinflammation · 2026-04-26
This hypothesis proposes that cytoplasmic mtDNA released from TDP-43-damaged mitochondria in ALS activates the cGAS-STIN
Score: 0.380 · immunomics · 2026-04-27
Elevated circulating high-sensitivity C-reactive protein (hs-CRP) serves as a disease-modifying target through direct ac
Score: 0.105 · neurodegeneration · 2026-04-18
## Mechanistic Overview NLRP3 Inflammasome Suppression via Selective Caspase-1 Inhibition starts from the claim that mod
Score: 0.000 · unknown disease · 2026-04-28
The NLRP3 inflammasome exhibits circadian oscillations regulated by BMAL1-dependent acetylation. Selective microglial ta