gene

IL18

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL18: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

338Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

IL18 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, inhibits. Associated with Atherosclerosis, Fibrosis, Inflammation. Connected to 97 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	IL18
Full Name	Interleukin-18
Chromosome	11q22.2-q22.3
Function	Gene expression: The IL18 gene is induced by NF-κB and AP-1 transcription factors in response to TLR ligands, TNF, and IL-1β
Molecular Weight	24 kDa
Amino Acids	192 aa
Pathways	NF-κB
UniProt ID	[Q14116](https://www.uniprot.org/uniprot/Q14116)
Ensembl ID	ENSG00000150782
GeneCards	IL18
Human Protein Atlas	IL18
Pro-IL-18 (24 kDa)	192 amino acid precursor
N-terminal propeptide	Removed by caspase-1 cleavage
Mature IL-18 (18 kDa)	157 amino acid active cytokine
β-trefoil fold	Characteristic of IL-1 cytokine family
Associated Diseases	ALS, Alcohol Use Disorder, Alzheimer, Fibrosis, Inflammation, Ms
Interactions	FKBP5, CRH, CRHR1, NR3C1, BDNF, TNF
KG Connections	338 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    IL18["IL18"] -->|"activates"| Ms["Ms"]
    IL18["IL18"] -->|"associated"| Tumor["Tumor"]
    IL18["IL18"] -->|"activates"| Inflammation["Inflammation"]
    IL18["IL18"] -.->|"inhibits"| Ms_1["Ms"]
    IL18["IL18"] -->|"activates"| Tumor_2["Tumor"]
    IL18["IL18"] -->|"activates"| Atherosclerosis["Atherosclerosis"]
    NLRP3_INFLAMMASOME["NLRP3_INFLAMMASOME"] -->|"produces"| IL18["IL18"]
    IL1B["IL1B"] -->|"associated"| IL18["IL18"]
    ATG5["ATG5"] -->|"associated"| IL18["IL18"]
    TNF["TNF"] -->|"associated"| IL18["IL18"]
    style IL18 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (197)

Target	Relation	Type	Str
Oxaliplatin-Induced Peripheral Neuropathy	causes	disease	0.90
Pyroptosis	mediates	process	0.90
Pyroptosis	promotes	process	0.85
Pyroptosis	product_of	process	0.80
Neuroinflammation	promotes	process	0.80
Tumor	associated_with	disease	0.75
Autophagy	associated_with	pathway	0.70
Toll-Like Receptor	associated_with	pathway	0.70
pyroptosis	participates_in	pathway	0.70
Alcohol Use Disorder	associated_with	disease	0.65
Ptsd	inhibits	disease	0.65
P2RX7	inhibits	gene	0.65
Ms	activates	disease	0.65
Inflammation	activates	disease	0.65
Ms	inhibits	disease	0.65
Tumor	activates	disease	0.65
Atherosclerosis	activates	disease	0.65
Fibrosis	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Fibrosis	inhibits	disease	0.65
Als	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Obesity	inhibits	disease	0.65
Cancer	activates	disease	0.65
Neuropathy	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Als	activates	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65
Obesity	activates	disease	0.65
Senescence	activates	disease	0.65
Pyroptosis	activates	disease	0.65
ALS	activates	disease	0.65
OXALIPLATIN	protects_against	drug	0.65
CASP1	associated_with	gene	0.60
ATG5	associated_with	gene	0.60
NLRC4	associated_with	gene	0.60
ASC	associated_with	gene	0.60
NLRP3	associated_with	gene	0.60
PYCARD	associated_with	gene	0.60
TNF	associated_with	gene	0.60
RAMP1	associated_with	gene	0.60
FKBP5	activates	gene	0.60
CRH	activates	gene	0.60
CRHR1	inhibits	gene	0.60
NR3C1	inhibits	gene	0.60
BDNF	activates	gene	0.60
IL18BP	associated_with	gene	0.60

Incoming (141)

Source	Relation	Type	Str
NLRP3	activates	protein	0.95
NLRP3 Inflammasome	associated_with	mechanism	0.95
Stress	downregulates	process	0.90
INFLAMMASOME COMPLEX	associated_with	protein	0.90
NLRP3 Inflammasome	upregulates	pathway	0.90
NLRP3 Inflammasome Activation	activates	process	0.90
NLRP3	upregulates	gene	0.90
NLRP3/caspase-1/GSDMD	upregulates	pathway	0.90
NLRP3	regulates	gene	0.90
Litebamine	downregulates	compound	0.90
NLRP3	promotes	protein	0.85
Familiar Context Stress	downregulates	process	0.85
CASP1	upregulates	gene	0.85
pyroptosis	promotes	process	0.85
Xiyangshen Sanqi Danshen Granules	downregulates	drug	0.80
ATG5	associated_with	gene	0.70
TNF	associated_with	gene	0.70
CASP1	associated_with	gene	0.70
GENES	associated_with	gene	0.70
AUTOPHAGY	associated_with	gene	0.70
NLRP3_INFLAMMASOME	produces	pathway	0.64
IL1B	associated_with	gene	0.60
NLRP3	associated_with	gene	0.60
NLRC4	associated_with	gene	0.60
CRHR1	inhibits	gene	0.60
CALCA	associated_with	gene	0.60
BDNF	activates	gene	0.60
ASC	associated_with	gene	0.60
CRH	activates	gene	0.60
VEGF	activates	gene	0.60
CXCL8	associated_with	gene	0.60
CCL4	associated_with	gene	0.60
IL7	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
CD4	activates	gene	0.60
UBIQUITIN	associated_with	gene	0.60
FKBP5	activates	gene	0.60
RAMP1	associated_with	gene	0.60
NR3C1	inhibits	gene	0.60
PYCARD	associated_with	gene	0.60
IL18BP	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
FIP200	associated_with	gene	0.60
RB1	associated_with	gene	0.60
IFNG	associated_with	gene	0.60
LC3	associated_with	gene	0.60
ATG14	associated_with	gene	0.60
MAP1LC3A	associated_with	gene	0.60
TLR4	associated_with	gene	0.60
S100A8	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

IL18

Understanding Entity Pages

Summary

Wiki Pages (21)

IL18 Gene

Neuroinflammation in Parkinson's Disease

Neuroinflammatory Cytokine Storm in Neurodegeneration

OPTN (Optineurin) Mitophagy Dysfunction — ALS/FTD/PD Causal Chain

Neuroinflammation in [Parkinson's Disease](/diseases/parkinsons-disease)

NLRP7 — NLR Family Pyrin Domain Containing 7

Stress Granule Formation in Neurodegeneration

Stress Granule-Associated Neurons

Stress Granules and RNP Granules

IL-18 - Interleukin-18

NLRC3 — NLR Family CARD Domain Containing 3

Stress Granule Modulation Therapy

Interleukin-18 Protein

Pyroptosis Inhibitors for Neurodegeneration — Investment Landscape Analysis

Microglia in Chronic Neuroinflammation

Stress Granules in Neurodegeneration

NLRP3 Inflammasome

PYCARD Gene

NEK7 Gene