gene

IL1B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL1B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1865Connections

0Hypotheses

3Analyses

50Outgoing

50Incoming

Summary

IL1B is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, interacts with. Associated with AD, ALS, AMI. Connected to 694 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	IL1B
Full Name	Interleukin 1 Beta
Chromosome	2q14.1
Protein Type	Ligand
Target Class	Ligand
Function	IL-1 receptor antagonist or neutralizing monoclonal antibody
Mechanism of Action	IL-1 receptor antagonist or neutralizing monoclonal antibody
Druggability	Medium (0.49)
Clinical Stage	Approved
Molecular Weight	31 kDa
Amino Acids	269 aa
Exons	7
Pathways	Akt, Apoptosis, Epigenetic, Mapk, Oxidative Stress
UniProt ID	O43645
NCBI Gene ID	3553
Ensembl ID	ENSG00000125538
OMIM	164520
GeneCards	IL1B
Human Protein Atlas	IL1B
Associated Diseases	AD, ALS, AMI, Aging, Alzheimer
Known Drugs/Compounds	Berberine, berberine, Guhan Yangsheng Jing, resveratrol, ANTHOCYANINS, rapamycin
Interactions	NLRP3, CASP1, PYCARD, SLC7A11, GPX4, TP53
SciDEX Target	View Target Profile (8 clinical trials)
KG Connections	1865 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure: IL1B — PDB 1I1B Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    IL1B(["IL1B"])
    Inflammation["Inflammation"]
    inflammatory_diseases["inflammatory diseases"]
    Neuroinflammation("Neuroinflammation")
    h_e7e1f943["h-e7e1f943"]
    INFLAMMASOME_COMPLEX(["INFLAMMASOME COMPLEX"])
    NLRP3_Inflammasome["NLRP3 Inflammasome"]
    Inflammasome["Inflammasome"]
    Autophagy["Autophagy"]
    TNF(["TNF"])
    Als["Als"]
    Myeloid_Cell_Immune_Response("Myeloid Cell Immune Response")
    Infection["Infection"]
    CASP1["CASP1"]

    IL1B -->|"activates"| Inflammation
    IL1B -->|"causes"| inflammatory_diseases
    IL1B -->|"mediates"| Neuroinflammation
    h_e7e1f943 -->|"therapeutic target"| IL1B
    INFLAMMASOME_COMPLEX -->|"associated with"| IL1B
    h_e7e1f943 -->|"targets gene"| IL1B
    NLRP3_Inflammasome -->|"upregulates"| IL1B
    Inflammasome -->|"associated with"| IL1B
    IL1B -->|"activates"| Autophagy
    TNF -->|"activates"| IL1B
    IL1B -->|"activates"| Als
    IL1B -->|"mediates"| Myeloid_Cell_Immune_Response
    IL1B -->|"activates"| Infection
    IL1B -->|"involved in"| Neuroinflammation
    CASP1 -->|"activates"| IL1B

    style IL1B fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (1153)

Target	Relation	Type	Str
Innate Immune Memory	associated_with	process	0.95
Inflammation	activates	disease	0.95
neuroinflammation	promotes	process	0.92
inflammatory diseases	causes	disease	0.90
Cardiac Dysfunction	mediates	phenotype	0.90
Epigenetic Changes	regulates	mechanism	0.90
MMP	activates	enzyme	0.90
myeloid cell immune response	activates	process	0.90
NLRP3	co_mentioned_with	gene	0.90
neuroinflammation	drives	process	0.90
neuroinflammation	mediates	process	0.90
Myeloid Cell Immune Response	involved_in	process	0.90
Neuroinflammation	mediates	process	0.90
Pyroptosis	mediates	process	0.90
MICROGLIA	expressed_in	cell_type	0.90
Parkinson's Disease	promotes	disease	0.90
Autophagy	activates	pathway	0.90
inflammatory activation	mediates	process	0.88
inflammation	mediates	process	0.88
Parkinson'S Disease	contributes_to	disease	0.87
Myeloid Cell Immune Response	mediates	process	0.85
Vascular Remodelling	contributes_to	process	0.85
POEMS Syndrome	involved_in	disease	0.85
Staphylococcus Aureus Infection	involved_in	disease	0.85
Staphylococcus Aureus Infection	mediates	disease	0.85
Comorbidities	contributes_to	phenotype	0.85
Retinal dysfunction	contributes_to	phenotype	0.85
MMP9	upregulates	protein	0.85
Sepsis-Associated Encephalopathy	contributes_to	disease	0.85
Als	activates	disease	0.85
Infection	activates	disease	0.85
Neuroinflammation	involved_in	process	0.85
Retinal Ganglion Cell Dysfunction	causes	phenotype	0.82
Osteoclast Differentiation	regulates	process	0.80
TNF Signaling Pathway	involved_in	pathway	0.80
spinal cord injury inflammation	mediates	process	0.80
TLR4	co_mentioned_with	gene	0.80
TNFA	co_mentioned_with	gene	0.80
Spinal Cord Injury	contributes_to	disease	0.80
MAPT	promotes	gene	0.80
Pyroptosis	product_of	process	0.80
NF-kB signaling	participates_in	pathway	0.80
pyroptosis	participates_in	pathway	0.80
HSV-1	regulates	entity	0.80
apoptosis pathway	participates_in	pathway	0.80
oxidative stress response	participates_in	pathway	0.80
autophagy pathway	participates_in	pathway	0.80
ubiquitin-proteasome	participates_in	pathway	0.80
IL6	activates	gene	0.80
AQP4	downregulates	gene	0.80

Incoming (712)

Source	Relation	Type	Str
Berberine	inhibits	compound	0.95
Safranal	downregulates	compound	0.95
Spike Protein 1	upregulates	protein	0.95
Cyclosporine A	upregulates	drug	0.92
Lapiferin	downregulates	compound	0.92
Nlrp3 Inflammasome	upregulates	pathway	0.92
NLRP3	upregulates	protein	0.91
INFLAMMASOME COMPLEX	associated_with	protein	0.90
NLRP3 Inflammasome	upregulates	pathway	0.90
Ric	downregulates	process	0.90
NLRP3 Inflammasome Activation	activates	process	0.90
Caspase-1	cleaves	protein	0.90
Betulinic Acid	downregulates	compound	0.90
Itaconate	downregulates	compound	0.90
Gallic Acid	downregulates	compound	0.90
Hearing Loss	upregulates	phenotype	0.90
high glucose	upregulates	compound	0.90
NLRP3/caspase-1/GSDMD	upregulates	pathway	0.90
Ginsenoside Re	downregulates	compound	0.90
Mbdnf@Αitgev	downregulates	compound	0.90
GS-1	downregulates	compound	0.90
Litebamine	downregulates	compound	0.90
AMS-17	downregulates	drug	0.90
microglia	upregulates	cell_type	0.90
h-e7e1f943	targets_gene	hypothesis	0.90
h-cc1076c1	targets_gene	hypothesis	0.90
h-var-6957745fea	targets_gene	hypothesis	0.90
h-var-08a4d5c07a	targets_gene	hypothesis	0.90
h-var-d04a952932	targets_gene	hypothesis	0.90
h-var-adfecef68a	targets_gene	hypothesis	0.90
h-var-af9eb8e59b	targets_gene	hypothesis	0.90
h-var-a0933e666d	targets_gene	hypothesis	0.90
TNF	activates	gene	0.90
Kaempferol	downregulates	compound	0.88
NF-κB Signaling	upregulates	pathway	0.88
NLRP3 inflammasome	activates	pathway	0.88
Microglia	expressed_in	cell_type	0.88
NFKB2	regulates	gene	0.87
NLRP3 Inflammasome	activates	process	0.85
Ams-17	downregulates	compound	0.85
NLRP3	regulates	protein	0.85
kaempferol	downregulates	compound	0.85
NLRP3	promotes	protein	0.85
Irisin	downregulates	protein	0.85
STING	upregulates	protein	0.85
ROS overproduction	upregulates	process	0.85
Guhan Yangsheng Jing	inhibits	drug	0.85
Glucose	upregulates	compound	0.85
IL17	upregulates	pathway	0.85
pyroptosis	promotes	process	0.85

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (3)

Scientific analyses that reference this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

IL1B

Understanding Entity Pages

Summary

Wiki Pages (21)

Interleukin-1 Beta (IL-1β) - Biomarker

cbs-psp-daily-action-plan

CBS/PSP Supplements Guide

coq10-neurodegeneration

omega-3-fatty-acids-neurodegeneration

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

Pathway Diagram

Outgoing (1153)

Incoming (712)

Targeting Hypotheses (0)

Mentioning Analyses (3)

Neuroinflammation and microglial priming in early Alzheimer's Disease

Senolytic therapy for age-related neurodegeneration

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

Related Papers (0)

IL1B

Understanding Entity Pages

Summary

Wiki Pages (21)

Interleukin-1 Beta (IL-1β) - Biomarker

cbs-psp-daily-action-plan

CBS/PSP Supplements Guide

coq10-neurodegeneration

omega-3-fatty-acids-neurodegeneration

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

Sulforaphane and Nrf2 Activation for Neuroprotection

Coenzyme Q10 for Neurodegeneration

deferiprone-neurodegeneration

Glia-Neuron Crosstalk in Alzheimer's Disease

vitamin-d-therapy-neurodegeneration

Neuroprotection Strategies in Neurodegeneration

Curcumin for Neurodegeneration

Mediterranean and MIND Diets for Neurodegeneration

creatine-supplementation-neurodegeneration

Ambroxol for Neurodegeneration (GCase Chaperone Strategy)

NAD+ Precursors for Neurodegeneration

NF-kB Signaling Pathway in Neurodegeneration

Creatine for Neuroprotection

tudca-udca-neurodegeneration

Psychobiotic Therapy for Neurodegenerative Diseases

Pathway Diagram

Outgoing (1153)

Incoming (712)

Targeting Hypotheses (0)

Mentioning Analyses (3)

Neuroinflammation and microglial priming in early Alzheimer's Disease

Senolytic therapy for age-related neurodegeneration

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

Related Papers (0)