gene

IL1B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL1B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1832Connections

2Hypotheses

10Analyses

50Outgoing

50Incoming

0Experiments

12Debates

Summary

IL1B is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, interacts with. Associated with AD, ALS, AMI. Connected to 694 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	IL1B
Full Name	Interleukin-1 Beta
Chromosome	2q14.1
Protein Type	Ligand
Target Class	Ligand
Function	IL-1 receptor antagonist or neutralizing monoclonal antibody
Mechanism of Action	IL-1 receptor antagonist or neutralizing monoclonal antibody
Subcellular Localization	</th><td>Secreted, cytosol</td></tr>
Druggability	Medium (0.49)
Clinical Stage	Approved
Molecular Weight	31 kDa
Amino Acids	269 aa
Exons	7
Pathways	Akt, Apoptosis, Epigenetic, Mapk, Oxidative Stress
UniProt ID	O43645
NCBI Gene ID	3553
Ensembl ID	ENSG00000125538
OMIM	164520
GeneCards	IL1B
Human Protein Atlas	IL1B
Associated Diseases	AD, Aging, Als, Alzheimer
Known Drugs/Compounds	ANTHOCYANINS, berberine, Berberine, Guhan Yangsheng Jing, HDAC3 inhibition, rapamycin
Interactions	A2M, ACACA, ACHE, ACTB, Actin, ADAM17
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Peripheral-to-Central Inflammation Circuit Breaker Neuroinflammation Biomarker-Guided Immunomodulatio
KG Connections	1831 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure Comparison — IL1B Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

1I1B — X-ray / Cryo-EM

🔮 AI Predicted Structure

O43645 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

IL1B — Interleukin-1 Beta

protein · 1526 words

→

IL1B Gene - Interleukin 1 Beta

gene · 754 words

→

Pathway Diagram

flowchart TD
    IL1B(["IL1B"])
    Inflammation["Inflammation"]
    inflammatory_diseases["inflammatory diseases"]
    Neuroinflammation("Neuroinflammation")
    h_e7e1f943["h-e7e1f943"]
    INFLAMMASOME_COMPLEX(["INFLAMMASOME COMPLEX"])
    NLRP3_Inflammasome["NLRP3 Inflammasome"]
    Inflammasome["Inflammasome"]
    Autophagy["Autophagy"]
    TNF(["TNF"])
    Als["Als"]
    Myeloid_Cell_Immune_Response("Myeloid Cell Immune Response")
    Infection["Infection"]
    CASP1["CASP1"]

    IL1B -->|"activates"| Inflammation
    IL1B -->|"causes"| inflammatory_diseases
    IL1B -->|"mediates"| Neuroinflammation
    h_e7e1f943 -->|"therapeutic target"| IL1B
    INFLAMMASOME_COMPLEX -->|"associated with"| IL1B
    h_e7e1f943 -->|"targets gene"| IL1B
    NLRP3_Inflammasome -->|"upregulates"| IL1B
    Inflammasome -->|"associated with"| IL1B
    IL1B -->|"activates"| Autophagy
    TNF -->|"activates"| IL1B
    IL1B -->|"activates"| Als
    IL1B -->|"mediates"| Myeloid_Cell_Immune_Response
    IL1B -->|"activates"| Infection
    IL1B -->|"involved in"| Neuroinflammation
    CASP1 -->|"activates"| IL1B

    style IL1B fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (1132)

Target	Relation	Type	Str
IL1B	encodes	protein	0.00
Inflammation	activates	disease	0.95
Innate Immune Memory	associated_with	process	0.95
neuroinflammation	promotes	process	0.92
neuroinflammation	mediates	process	0.90
Parkinson's Disease	promotes	disease	0.90
Myeloid Cell Immune Response	involved_in	process	0.90
Pyroptosis	mediates	process	0.90
MICROGLIA	expressed_in	cell_type	0.90
NLRP3	associated_with	protein	0.90
Epigenetic Changes	regulates	mechanism	0.90
MMP	activates	enzyme	0.90
myeloid cell immune response	activates	process	0.90
Neuroinflammation	mediates	process	0.90
neuroinflammation	drives	process	0.90
caspase-1	part_of	protein	0.90
Cardiac Dysfunction	mediates	phenotype	0.90
inflammatory diseases	causes	disease	0.90
Autophagy	activates	pathway	0.90
inflammatory activation	mediates	process	0.88
inflammation	mediates	process	0.88
Parkinson'S Disease	contributes_to	disease	0.87
Sepsis-Associated Encephalopathy	contributes_to	disease	0.85
Infection	activates	disease	0.85
Neuroinflammation	involved_in	process	0.85
MMP9	upregulates	protein	0.85
Myeloid Cell Immune Response	mediates	process	0.85
Als	activates	disease	0.85
POEMS Syndrome	involved_in	disease	0.85
Retinal dysfunction	contributes_to	phenotype	0.85
Comorbidities	contributes_to	phenotype	0.85
Vascular Remodelling	contributes_to	process	0.85
Staphylococcus Aureus Infection	involved_in	disease	0.85
Staphylococcus Aureus Infection	mediates	disease	0.85
Retinal Ganglion Cell Dysfunction	causes	phenotype	0.82
HSV-1	regulates	entity	0.80
TLR4	associated_with	gene	0.80
TNFA	associated_with	gene	0.80
Spinal Cord Injury	contributes_to	disease	0.80
oxidative stress response	participates_in	pathway	0.80
ubiquitin-proteasome	participates_in	pathway	0.80
apoptosis pathway	participates_in	pathway	0.80
autophagy pathway	participates_in	pathway	0.80
MAPT	associated_with	gene	0.80
Pyroptosis	product_of	process	0.80
pyroptosis	participates_in	pathway	0.80
NF-kB signaling	participates_in	pathway	0.80
TREM-1	part_of	protein	0.80
TNF Signaling Pathway	involved_in	pathway	0.80
Osteoclast Differentiation	regulates	process	0.80

Incoming (700)

Source	Relation	Type	Str
IL1B	encodes	gene	0.00
Safranal	downregulates	compound	0.95
Spike Protein 1	upregulates	protein	0.95
Berberine	inhibits	compound	0.95
Cyclosporine A	upregulates	drug	0.92
Lapiferin	downregulates	compound	0.92
Nlrp3 Inflammasome	upregulates	pathway	0.92
NLRP3	upregulates	protein	0.91
h-var-6957745fea	targets_gene	hypothesis	0.90
h-var-d04a952932	targets_gene	hypothesis	0.90
h-var-adfecef68a	targets_gene	hypothesis	0.90
h-e7e1f943	targets	hypothesis	0.90
h-cc1076c1	targets	hypothesis	0.90
high glucose	upregulates	compound	0.90
h-var-08a4d5c07a	targets_gene	hypothesis	0.90
NLRP3 Inflammasome Activation	activates	process	0.90
NLRP3/caspase-1/GSDMD	upregulates	pathway	0.90
Hearing Loss	upregulates	phenotype	0.90
microglia	upregulates	cell_type	0.90
h-var-a0933e666d	targets_gene	hypothesis	0.90
INFLAMMASOME COMPLEX	associated_with	protein	0.90
Itaconate	downregulates	compound	0.90
NLRP3 Inflammasome	upregulates	pathway	0.90
Ginsenoside Re	downregulates	compound	0.90
Gallic Acid	downregulates	compound	0.90
h-var-af9eb8e59b	targets_gene	hypothesis	0.90
Litebamine	downregulates	compound	0.90
Mbdnf@Αitgev	downregulates	compound	0.90
GS-1	downregulates	compound	0.90
Ric	downregulates	process	0.90
AMS-17	downregulates	drug	0.90
Caspase-1	cleaves	protein	0.90
Betulinic Acid	downregulates	compound	0.90
TNF	activates	gene	0.90
NLRP3 inflammasome	activates	pathway	0.88
NF-κB Signaling	upregulates	pathway	0.88
Microglia	expressed_in	cell_type	0.88
Kaempferol	downregulates	compound	0.88
NFKB2	regulates	gene	0.87
IL17	upregulates	pathway	0.85
Nlrp3 Inflammasome	activates	process	0.85
STING	upregulates	protein	0.85
Irisin	downregulates	protein	0.85
NLRP3	associated_with	protein	0.85
NLRP3 Inflammasome	activates	process	0.85
Guhan Yangsheng Jing	inhibits	drug	0.85
ROS overproduction	upregulates	process	0.85
pyroptosis	promotes	process	0.85
Ams-17	downregulates	compound	0.85
Glucose	upregulates	compound	0.85

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Peripheral-to-Central Inflammation Circuit Breaker	0.626	-	Blood-brain barrier tight junction disru
Neuroinflammation Biomarker-Guided Immunomodulation for GBA	0.000	-	GBA-Synuclein Loop: Therapeutic Strategi

Mentioning Analyses (10)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (12)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning IL1B in their description or question text

No additional research found

IL1B

Understanding Entity Pages

Summary

Wiki Pages (2)

IL1B — Interleukin-1 Beta

IL1B Gene - Interleukin 1 Beta

Pathway Diagram

Outgoing (1132)

Incoming (700)

Targeting Hypotheses (2)

Mentioning Analyses (10)

Blood-brain barrier tight junction disruption by neuroinflammatory cytokines

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

Do tau strains or regional cellular environments primarily drive PSP vs CBD path

How can CNS-selective HDAC/DNMT inhibitors be developed to avoid systemic toxici

How does sevoflurane-induced NF-κB activation specifically trigger complement ca

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas

Senolytic therapy for age-related neurodegeneration

GBA-Synuclein Loop: Therapeutic Strategies for Parkinson's Disease

Senolytic therapy for age-related neurodegeneration

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

Experiments (0)

Related Papers (0)

Debates (12)

Hypothesis debate: SASP-Mediated Complement Cascade Amplification

Should PEA-PPARA endocannabinoid signaling be prioritized as a therapeutic strat

While the study demonstrates both NF-κB pathway activation and increased C1qa ex

Both theorist and domain expert acknowledged that existing epigenetic modulators

The core debate question remains unresolved - whether intrinsic tau conformation

Blood-brain barrier tight junction disruption by neuroinflammatory cytokines

The abstract shows HDAC9 overexpression reduces Aβ deposition and improves synap

GBA-Synuclein Loop: Therapeutic Strategies for Parkinson's Disease?

Senolytics targeting p16/p21+ senescent astrocytes and microglia may reduce SASP

Cell-type specific expression patterns of neurodegeneration genes in SEA-AD

Related Research