gene

NTSR1

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about NTSR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

NTSR1 encodes a GPCR for neurotensin that modulates dopamine signaling, with roles in Parkinson's disease, schizophrenia, and cancer.

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🧬 Gene Info

Gene Symbol	NTSR1
Full Name	Neurotensin Receptor 1
Chromosome	2q24.1
Protein Type	Receptor
Function	encodes a G protein-coupled receptor (GPCR) that binds the neuropeptide neurotensin (NT) with high affinity (Kd ~ 0.
Primary Expression	regions rich in dopaminergic neurons, where it plays a critical role in modulating dopamine signaling andMotor contr
Amino Acids	418 aa
Pathways	MAPK
UniProt ID	[P21439](https://www.uniprot.org/uniprot/P21439)
Ensembl ID	ENSG00000102468
OMIM	162650
GeneCards	NTSR1
Human Protein Atlas	NTSR1
Associated Diseases	Parkinson's disease, Alzheimer's disease
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NTSR1 — Neurotensin Receptor 1

gene · 1483 words

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Pathway Diagram

graph TD
    NTSR1["NTSR1"]
    neurodegeneration["neurodegeneration"]
    NTSR1 -->|"implicated_in"| neurodegeneration
    style NTSR1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning NTSR1 in their description or question text

No additional research found