Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NUPL2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | NUPL2 |
| Aliases | Nucleoporin Like 2 |
| Chromosome | 7p15.3 |
| Function | is a gene encoding a protein component of the nuclear pore complex (NPC). |
| Molecular Weight | 55 kDa |
| Amino Acids | 463 aa |
| Ensembl ID | ENSG00000168214 |
| GeneCards | NUPL2 |
| Human Protein Atlas | NUPL2 |
| Nuclear ring | Anchors the pore to the nuclear envelope |
| Cytoplasmic ring | Faces the cytoplasm |
| Central channel | Contains FG-nucleoporins forming the permeability barrier |
| Nuclear basket | Extends into the nucleoplasm |
| Protein import | Nuclear localization signals (NLS) are recognized by importins, facilitating protein import into the nucleus |
| Protein export | Nuclear export signals (NES) direct proteins to the cytoplasm |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
NUPL2["NUPL2"]
neurodegeneration["neurodegeneration"]
NUPL2 -->|"implicated_in"| neurodegeneration
style NUPL2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning NUPL2 in their description or question text
No additional research found