Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Nucleocytoplasmic transport disruption: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| synaptic proteostasis failure | causes | mechanism | 0.70 |
| als | associated_with | disease | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TDP-43 pathology | causes | process | 0.70 |
| C9orf72 | causes | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Nucleocytoplasmic Transport Disruption | 0.520 | neurodegeneration | What mechanisms underlie TDP-43's contri |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-18 | 4 hypotheses Top: 0.538
neurodegeneration | 2026-04-08 | 5 hypotheses Top: 0.680
neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.720
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.73 · 2026-04-21
closed · Rounds: 4 · Score: 0.50 · 2026-04-18
closed · Rounds: 4 · Score: 0.72 · 2026-04-12
closed · Rounds: 4 · Score: 0.88 · 2026-04-06
Hypotheses and analyses mentioning Nucleocytoplasmic transport disruption in their description or question text
No additional research found