Als

Understanding Entity Pages

This page aggregates everything SciDEX knows about Als: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting motor neurons in the brain and spinal cord. ALS leads to muscle weakness, atrophy, and eventual paralysis. Key genetic factors include mutations in SOD1, C9orf72, TDP-43, and FUS. Pathological mechanisms involve protein aggregation, RNA metabolism dysfunction, mitochondrial impairment, excitotoxicity, and neuroinflammation. The disease has a median survival of 3-5 years from symptom onset.

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graph TD
    subgraph Therapeutic["Therapeutic"]
        Als["Als"] -->|"therapeutic target"| Wnt["Wnt"]
        Als["Als"] -->|"therapeutic target"| Apoptosis["Apoptosis"]
        JUN["JUN"] -->|"therapeutic target"| Als["Als"]
    end
    subgraph Signaling["Signaling"]
        Als["Als"] -->|"activates"| Glycolysis["Glycolysis"]
        Als["Als"] -.->|"inhibits"| Mtor["Mtor"]
        Als["Als"] -->|"activates"| Complement["Complement"]
        Als["Als"] -->|"activates"| Phagocytosis["Phagocytosis"]
        Als["Als"] -->|"activates"| Nf__b["Nf-Kappab"]
        GAIN["GAIN"] -->|"activates"| Als["Als"]
        MTOR["MTOR"] -.->|"inhibits"| Als["Als"]
        APOE["APOE"] -.->|"inhibits"| Als["Als"]
        JUN_1["JUN"] -->|"activates"| Als["Als"]
    end
    subgraph Interactions["Interactions"]
        Als["Als"] -->|"interacts with"| Autophagy["Autophagy"]
        LC3["LC3"] -->|"interacts with"| Als["Als"]
    end
    subgraph Pathology["Pathology"]
        Als["Als"] -->|"associated with"| Neuroinflammation["Neuroinflammation"]
    end
    style Als fill:#ef5350,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
    style Wnt fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Glycolysis fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Autophagy fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Mtor fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Complement fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Phagocytosis fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Nf__b fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Neuroinflammation fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Apoptosis fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style JUN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style GAIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style LC3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style MTOR fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style APOE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style JUN_1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0