gene

PARD6G

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about PARD6G: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

PARD6G encodes a component of the PAR polarity complex essential for neuronal development, synaptic function, and implicated in neurodegeneration through roles in cell polarity, protein trafficking, and neuronal connectivity.

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🧬 Gene Info

Gene Symbol	PARD6G
Full Name	Partitioning Defect 6 Par-6 Family Cell Polarity Protein Gamma
Chromosome	18q22.1
Function	encodes a component of the PAR (Partitioning Defect) polarity complex, a key regulator of cell polarity in eukaryotic cells[@ridley2019].
Primary Expression	both excitatory and inhibitory neurons throughout the brain, with particularly high levels in the hippocampus and cerebral cortex
Molecular Weight	38 kDa
Amino Acids	346 aa
Exons	10
GeneCards	PARD6G
Human Protein Atlas	PARD6G
N-terminal PDZ domain	Mediates interactions with polarity proteins and membrane receptors
C-terminal semi-CRIB domain	Required for CDC42/Rac interaction
Polyproline region	Involved in protein-protein interactions
S/T-rich C-terminal tail	Site of regulatory phosphorylation
PARD6A	Ubiquitous expression, highest in epithelial tissues
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PARD6G — Partitioning Defect 6 Par-6 Family Cell Polarity Protein Gamma

gene · 1726 words

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Pathway Diagram

graph TD
    PARD6G["PARD6G"]
    neurodegeneration["neurodegeneration"]
    PARD6G -->|"implicated_in"| neurodegeneration
    style PARD6G fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning PARD6G in their description or question text

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