gene

PDE2A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PDE2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

0Hypotheses

0Analyses

1Outgoing

0Incoming

0Experiments

Summary

PDE2A Gene

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🧬 Gene Info

Gene Symbol	PDE2A
Full Name	Phosphodiesterase 2A
Chromosome	11q13.4
Function	PDE2A is a dual-specificity phosphodiesterase that hydrolyzes both cAMP and cGMP with equal efficiency.
Primary Expression	brain and regulates synaptic plasticity, memory, and emotional behavior [^domeklopacinska2016][^epifantseva2019]
UniProt ID	[O76074](https://www.uniprot.org/uniprotkb/O76074/entry)
NCBI Gene ID	5139
Ensembl ID	ENSG00000186642
OMIM	602952
GeneCards	PDE2A
Human Protein Atlas	PDE2A
Associated Diseases	Alzheimer's disease, cardiac function
KG Connections	1 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PDE2A["PDE2A Gene"]
    PDE2A_PROT["PDE2A Protein"]
    CAMP["cAMP"]
    CGMP["cGMP"]
    PKA["Protein Kinase A"]
    PKG["Protein Kinase G"]
    CREB["CREB Transcription Factor"]
    BDNF["BDNF"]
    SYNAPTIC_PLAST["Synaptic Plasticity"]
    MEMORY["Memory Formation"]
    NEUROINFLAM["Neuroinflammation"]
    OXID_STRESS["Oxidative Stress"]
    NEURODEGEN["Neurodegeneration"]
    PFOA["PFOA"]
    CALCIUM["Calcium Signaling"]
    MITOCHONDRIA["Mitochondrial Function"]

    PDE2A -->|"encodes"| PDE2A_PROT
    PDE2A_PROT -->|"hydrolyzes"| CAMP
    PDE2A_PROT -->|"hydrolyzes"| CGMP
    CAMP -->|"activates"| PKA
    CGMP -->|"activates"| PKG
    PKA -->|"phosphorylates"| CREB
    PKG -->|"activates"| CREB
    CREB -->|"transcribes"| BDNF
    BDNF -->|"promotes"| SYNAPTIC_PLAST
    SYNAPTIC_PLAST -->|"enhances"| MEMORY
    CGMP -->|"regulates"| CALCIUM
    CALCIUM -->|"affects"| MITOCHONDRIA
    MITOCHONDRIA -->|"dysfunction leads to"| OXID_STRESS
    OXID_STRESS -->|"triggers"| NEUROINFLAM
    NEUROINFLAM -->|"promotes"| NEURODEGEN
    PFOA -->|"binds to"| PDE2A_PROT

    style PDE2A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
    style PDE2A_PROT fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
    style SYNAPTIC_PLAST fill:#1a3a2a,stroke:#81c784,stroke-width:2px
    style MEMORY fill:#1a3a2a,stroke:#81c784,stroke-width:2px
    style BDNF fill:#1a3a2a,stroke:#81c784,stroke-width:2px
    style CREB fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px
    style PKA fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px
    style PKG fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px
    style NEUROINFLAM fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
    style OXID_STRESS fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
    style NEURODEGEN fill:#3a2a1a,stroke:#ffa726,stroke-width:3px

Outgoing (1)

Target	Relation	Type	Str
PFOA	binds_to	drug	0.90

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PDE2A

Understanding Entity Pages

Summary

Wiki Pages (8)

PDE2A Gene

cGMP Signaling Pathway in Neurodegeneration

cAMP Signaling in Neurodegeneration

PDE4 Inhibitor PD Trial

Phosphodiesterase (PDE) Inhibitors for Neurodegeneration

Phosphodiesterase Inhibitors for Parkinson's Disease

Cognitive Enhancers for Neurodegeneration