protein 748 words KG: PEN2 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

Presenilin Enhancer 2 (PEN-2) Protein

🔬 Protein Info
Gene SymbolPSENEN
AliasesPresenilin Enhancer 2
Chromosome19q13.12
Protein FamilyPEN-2 family (γ-secretase complex)
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionEndoplasmic reticulum, Golgi apparatus, plasma membrane
Subcellular LocalizationEndoplasmic reticulum, Golgi apparatus, plasma membrane
Molecular Weight12 kDa
Amino Acids101 aa
PathwaysAngiogenesis
UniProt IDQ9NQ75
GeneCardsPSENEN
Human Protein AtlasPSENEN
GenePSENEN
PDB5A63, 6IDF
Associated DiseasesAD, AMI, Als, Alzheimer, Alzheimer'S Disease
InteractionsPSEN1, DAPK1, HSPG2, IL1B, APP, EIF2AK2
KG Connections98 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (11)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
PARP1 Inhibition Therapy
Score: 0.58
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53

Related Analyses (8)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (13)

Dynein Motor Protein
mechanism · KG edge: interacts_with
Alzheimer Indonesia
institution · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: interacts_with
EIF2AK2 — Eukaryotic Translation Initiation Factor 2 Al
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

PEN2 interacts_with PSEN1
PEN2 interacts_with DAPK1
PEN2 interacts_with HSPG2
PEN2 interacts_with IL1B
PEN2 interacts_with APP
PEN2 interacts_with EIF2AK2
PEN2 interacts_with APH1B
PEN2 interacts_with IL6
PEN2 interacts_with PARP1
PEN2 interacts_with HMGCR