gene

PEX16

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PEX16: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

PEX16 encodes peroxin-16, a critical peroxisomal membrane protein required for peroxisome biogenesis and implicated in neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	PEX16
Full Name	Peroxisome Biogenesis Factor 16
Chromosome	11p11.2
Protein Family	PEX proteins, peroxisome biogenesis factors
Function	encodes an essential peroxisomal membrane protein critical for early stages of peroxisome biogenesis.
Subcellular Localization	Peroxisomal membrane
Amino Acids	336 aa
UniProt ID	Q9Y5Y5
NCBI Gene ID	5494
Ensembl ID	ENSG00000121653
OMIM	603460
GeneCards	PEX16
Human Protein Atlas	PEX16
Fatty acid β-oxidation	Very long-chain fatty acids, dicarboxylic acids, pipecolic acid
Plasmalogen synthesis	Ether phospholipids critical for myelin
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PEX16 — AlphaFold Q9Y5Y5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PEX16 Gene

gene · 1384 words

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Pathway Diagram

graph TD
    PEX16["PEX16"]
    neurodegeneration["neurodegeneration"]
    PEX16 -->|"implicated_in"| neurodegeneration
    style PEX16 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning PEX16 in their description or question text

No additional research found