gene

PFEN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PFEN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3Connections

0Hypotheses

0Analyses

1Outgoing

2Incoming

Summary

PFN1 Gene

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🧬 Gene Info

Gene Symbol	PFN1
Full Name	Profilin 1
Chromosome	17p13.3
Protein Family	Profilin family
Function	regulating cytoskeletal dynamics
Molecular Weight	15 kDa
Amino Acids	140 aa
Exons	4
Pathways	Chaperone
UniProt ID	[P07737](https://www.uniprot.org/uniprot/P07737)
Ensembl ID	ENSG00000108518
OMIM	176610
GeneCards	PFN1
Human Protein Atlas	PFN1
Axon Guidance	Profilin-mediated actin dynamics essential for growth cone navigation
Associated Diseases	Als, Neurodegeneration, disease
Interactions	DNAJB6, ALS
SciDEX Hypotheses	Profilin-1 Cytoskeletal Checkpoint Enhancement
KG Connections	35 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PFN1 Gene

gene · 946 words

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Genes

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Pathway Diagram

graph TD
    PFEN1["PFEN1"]
    TREM2["TREM2"]
    OxPC["OxPC"]
    microglia["microglia"]
    neurodegeneration["neurodegeneration"]

    PFEN1 -->|"upregulates"| TREM2
    OxPC -->|"causes"| PFEN1
    microglia -->|"protects against"| PFEN1
    PFEN1 -->|"implicated in"| neurodegeneration

    style PFEN1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style TREM2 fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
    style OxPC fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff
    style microglia fill:#1a2a3a,stroke:#ffa726,stroke-width:2px,color:#fff
    style neurodegeneration fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff

Outgoing (1)

Target	Relation	Type	Str
TREM2	upregulates	gene	0.80

Incoming (2)

Source	Relation	Type	Str
OxPC	causes	chemical	0.80
microglia	protects_against	cell_type	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found