SciDEX — disease

disease

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about disease: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2322Connections

24Hypotheses

30Analyses

50Outgoing

50Incoming

Summary

disease is a disease characterized by neurodegeneration research. Key relationships include: implicated in, protects against. Connected to 100 entities in the SciDEX knowledge graph.

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Disease Info

Associated Genes	RAB7A, LRP2, ACTB, CTSD, ATG, EGFR, SREBF1, NADH
KG Connections	2304 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

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Clinical Management Guide for CBS/PSP

therapeutic · 15224 words

→

Progressive Supranuclear Palsy (PSP)

disease · 12907 words

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Pathway Diagram

graph TD
    autophagy["autophagy"] -->|"protects against"| disease["disease"]
    RAB7A["RAB7A"] -->|"implicated in"| disease["disease"]
    LRP2["LRP2"] -->|"implicated in"| disease["disease"]
    ACTB["ACTB"] -->|"implicated in"| disease["disease"]
    style disease fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (663)

Target	Relation	Type	Str
PPAR-Γ	activates	concept	0.50
PEROXISOME	activates	concept	0.50
PPAR-Γ	protects_against	concept	0.50
NEURODEGENERATIVE DISEASE	protects_against	concept	0.50
ALZHEIMER'S	associated_with	concept	0.50
ALZHEIMER'S	inhibits	concept	0.50
ALZHEIMER'S	interacts_with	concept	0.50
ALZHEIMER'S	protects_against	concept	0.50
Cognitive Impairment	inhibits	phenotype	0.50
GENETIC MODIFIERS	associated_with	concept	0.50
Bipolar	interacts_with	disease	0.50
PARKINSON'S	interacts_with	concept	0.50
Pain	interacts_with	disease	0.50
ALZHEIMER'S	causes	concept	0.50
Inflammatory Bowel Disease	associated_with	disease	0.50
CARDIOVASCULAR DISEASE	causes	concept	0.50
Proteins	interacts_with	protein	0.50
B CELLS	interacts_with	concept	0.50
ALZHEIMER'S	activates	concept	0.50
Proteins	associated_with	protein	0.50
Protein Aggregation	expressed_in	process	0.50
ALZHEIMER'S	expressed_in	concept	0.50
AMYLOID-β	expressed_in	concept	0.50
NEURODEGENERATIVE DISEASE	associated_with	concept	0.50
Infection	associated_with	disease	0.50
ENDOTHELIAL	activates	concept	0.50
FRONTOTEMPORAL	activates	concept	0.50
COPD	activates	disease	0.50
SYNUCLEIN	activates	concept	0.50
Reactive Oxygen Species	activates	process	0.50
NUCLEUS	activates	concept	0.50
ENDOPLASMIC RETICULUM	activates	concept	0.50
Proteins	activates	protein	0.50
STRESS GRANULES	activates	concept	0.50
PARKINSON'S	associated_with	concept	0.50
Fatty Liver	interacts_with	disease	0.50
NAFLD	associated_with	disease	0.50
AKT1S1	activates	concept	0.50
Crohn Disease	activates	disease	0.50
Cystic Fibrosis	activates	disease	0.50
Dendritic Cell	activates	cell_type	0.50
CYP1A1	activates	concept	0.50
DNA DAMAGE	activates	concept	0.50
COLORECTAL CANCER	activates	disease	0.50
Microrna	activates	pathway	0.50
Inflammatory Bowel Disease	activates	disease	0.50
RAPAMYCIN	activates	concept	0.50
ALZHEIMER'S	regulates	concept	0.50
SEROTONIN	regulates	concept	0.50
SEROTONIN	activates	concept	0.50

Incoming (1659)

Source	Relation	Type	Str
autophagy	protects_against	process	0.70
RAB7A	implicated_in	gene	0.50
LRP2	implicated_in	gene	0.50
ACTB	implicated_in	gene	0.50
CTSD	implicated_in	gene	0.50
ATG	implicated_in	gene	0.50
EGFR	implicated_in	gene	0.50
SREBF1	implicated_in	gene	0.50
NADH	implicated_in	gene	0.50
MTORC1	implicated_in	gene	0.50
PPARG	implicated_in	gene	0.50
RPS6KB1	implicated_in	gene	0.50
PPARA	implicated_in	gene	0.50
LAMP1	implicated_in	gene	0.50
RUBCN	implicated_in	gene	0.50
MTOR	implicated_in	gene	0.50
RAS	implicated_in	gene	0.50
RPS6	implicated_in	gene	0.50
PIK3C3	implicated_in	gene	0.50
ATP	implicated_in	gene	0.50
SQSTM1	implicated_in	gene	0.50
CAT	implicated_in	gene	0.50
PPAR	implicated_in	gene	0.50
ROS	implicated_in	gene	0.50
BACE1	implicated_in	gene	0.50
CD2AP	implicated_in	gene	0.50
RELN	implicated_in	gene	0.50
APOE	implicated_in	gene	0.50
HCN4	implicated_in	gene	0.50
HCN2	implicated_in	gene	0.50
HCN1	implicated_in	gene	0.50
SLC16A2	implicated_in	gene	0.50
SLC16A1	implicated_in	gene	0.50
GSS	implicated_in	gene	0.50
CYP2E1	implicated_in	gene	0.50
IDH2	implicated_in	gene	0.50
NAD	implicated_in	gene	0.50
IDH1	implicated_in	gene	0.50
MCU	implicated_in	gene	0.50
LETM1	implicated_in	gene	0.50
IBA1	implicated_in	gene	0.50
REL	implicated_in	gene	0.50
HSPG2	implicated_in	gene	0.50
DAPK1	implicated_in	gene	0.50
PARP1	implicated_in	gene	0.50
A2M	implicated_in	gene	0.50
DHCR24	implicated_in	gene	0.50
HMGCR	implicated_in	gene	0.50
IL6	implicated_in	gene	0.50
PSEN1	implicated_in	gene	0.50

Targeting Hypotheses (24)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop transcranial focused ultrasound to restore hippo	0.709	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound with 40Hz gamma	0.689	Alzheimer's disease	Circuit-level neural dynamics in neurode
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro	0.662	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
Closed-loop transcranial focused ultrasound to restore hippo	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode

Closed-loop tACS targeting entorhinal cortex layer II SST in	0.625	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.614	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.612	Alzheimer's disease	Circuit-level neural dynamics in neurode
Context-Dependent Cx43 Modulation Based on Disease Stage	0.579	cell biology	What is the relative contribution of con
Optogenetic restoration of hippocampal gamma oscillations vi	0.566	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic viral vector delivery via tFUS-mediated blood-br	0.557	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic restoration of hippocampal gamma oscillations vi	0.554	Alzheimer's disease	Circuit-level neural dynamics in neurode
40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Pri	0.515	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drive	0.512	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
Closed-loop transcranial focused ultrasound targeting CA1 PV	0.508	Alzheimer's disease	Circuit-level neural dynamics in neurode
Microglial TREM2 downregulation impairs damage-associated re	0.507	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V
Disease-Associated Microglia Metabolic Reprogramming	0.502	neurodegeneration	Cell type vulnerability in Alzheimers Di
GAS6/TAM Axis Activation Stabilizes Blood-Brain Barrier to R	0.498	neuroinflammation	Why do TAM receptors protect against neu
C1QA/C1QB Subunit-Specific Inhibition to Block Aberrant PV I	0.497	neurodegeneration	Are interneuron oscillation deficits com
ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligo	0.493	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferrop	0.493	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Sub	0.491	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vul	0.485	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
Epigenetic Memory Reprogramming for Alzheimer's Disease	0.467	neurodegeneration	CRISPR-based therapeutic approaches for

Mentioning Analyses (30)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
FAK/SRC-JNK axis promotes ferroptosis via upregulating ACSL4 expression. [PMID:41862445]	Qin J, Ma S, Wang J, Huang S, Luan J, He	Cell death & disease	2026
Quercetin attenuates ox-LDL-induced endothelial injury by regulating ferroptosis [PMID:41902795]	Gao C, Liu B, Zhang R, Tian J, Xin H	Toxicology mechanisms and meth	2026
NEDD8 promotes the ferritinophagy and ferroptosis of neurons in ischemic stroke [PMID:41662890]	Rao W, Huang Y, Li J, Chen Q, Sun J et a	J Stroke Cerebrovasc Dis	2026
Inhibition of Ferroptosis in Prostatitis Model by Low Intensity Extracorporeal S [PMID:41714892]	Lin D, Li K, Kuang W, Chen Z, Zhang M	World J Mens Health	2026
Deciphering sorafenib resistance in hepatocellular carcinoma via ferroptotic mec [PMID:41763496]	Che L, Zhu L, Zhou L, Zhou Y	Biochim Biophys Acta Rev Cance	2026
B4GALT1 deficiency attenuates steatohepatitis by regulating the PPARγ/ACSL4 axis [PMID:41860570]	Chien Y, Xia R, Zhou D, Ai Y, Wu L et al	Hepatol Commun	2026
[The Chinese medicine Gandouling attenuates brain injury in hepatolenticular deg [PMID:41946579]	Wu K, Wang N, Zhao D, Wei W, Zhang W et	Zhejiang Da Xue Xue Bao Yi Xue	2026
Unraveling the impact of risk factors on the ferroptosis-Alzheimer's disease lin [PMID:41498558]	Singh P, Rath SL	Journal of Alzheimer's disease	2026
Resveratrol Alleviates Intervertebral Disc Degeneration by Targeting NCOA4-Media [PMID:41873334]	Song C, Wu X, Chen C, Shen B, He Y, Liu	Drug design, development and t	2026
Pan-PPAR agonist bezafibrate alleviates psoriasis by suppressing LCN2-dependent [PMID:41662914]	["Xin R", "Zhang J", "Zhang Y", "Dai M",	Free radical biology & medicin	2026
Acteoside alleviates sepsis-induced acute lung injury by activating the Nrf2 pat [PMID:41895086]	Wang Y, Zhang W, Zhang M, Zhu Y, Wang W,	Tissue & cell	2026
Ferroptosis and microglial polarization in retinal vein occlusion: pathological [PMID:41924362]	Xu J, Sun M, Wang C, Ju P, Guan XD, Xie	International journal of ophth	2026
Gray matter structural and molecular signatures in Alzheimer's disease and late- [PMID:41419068]	Yang S, Wang X, Yan Y, Zhang J, Wei Y et	J Affect Disord	2026
Connexin 43 drives glioblastoma cancer stem cell phenotypes through a WNK lysine [PMID:40946315]	Mulkearns-Hubert EE, Hajdari N, Hong ES,	Cell Rep	2025
Integrative analysis of gene expression and histone modifications for DES, DSP, [PMID:41275133]	Saeed S, Hoffmann A, Svensson SIA, Visno	Mol Med	2025
Melatonin Alleviates Erastin-Induced Cell Death by Inhibiting Ferroptosis and Am [PMID:40442550]	Wongjaikam S, Siengdee P, Somnus A, Govi	Neurotoxicity research	2025
Microglial exosome TREM2 ameliorates ferroptosis and neuroinflammation in alzhei [PMID:40640358]	Zhu L, Zhou T, Wu L, Zhu X, Chen L, Zhan	Scientific reports	2025
Microbiota-derived lysophosphatidylcholine alleviates Alzheimer's disease pathol [PMID:39510074]	["Zha Xu", "Liu Xicheng", "Wei Mengping"	Cell metabolism	2025
Upregulation of MAM by C99 disrupts ACSL4 activity and phospholipid homeostasis [PMID:41394684]	Montesinos J, Yun TD, Salomón-Cruz ID, A	bioRxiv : the preprint server	2025
Danggui Shaoyao San ameliorates Alzheimer's disease by regulating lipid metaboli [PMID:40271063]	Gong K, Zhou S, Xiao L, Xu M, Zhou Y, Lu	Frontiers in pharmacology	2025

disease

Understanding Entity Pages

Summary

Wiki Pages (21)

Isomorphic Labs (DeepMind spinout)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

primary-progressive-aphasia

CBS/PSP Supplements Guide

Atypical Parkinsonism

Device Therapies Comparison for CBS/PSP

Parthanatos in Neurodegeneration

CBS/PSP Rehabilitation Master Guide

calcium-dysregulation-comparison

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Alpha-Synuclein Pathology

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

Pathway Diagram

Outgoing (663)

Incoming (1659)

Targeting Hypotheses (24)

Mentioning Analyses (30)

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

What are the precise temporal dynamics of astrocyte ketone production decline du

Should microtubule-stabilizing drugs be reconsidered as therapeutic targets for

What are the physiological functions of BACE1 beyond APP processing that could c

What molecular mechanisms cause iPLA2β deficiency to specifically damage mitocho

Why does autophagy inhibition improve neuronal survival when autophagy is typica

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

Why does Metformin fail to delay CJD progression despite improving anti-aging ha

How does FUS loss-of-function in TAZ regulation contribute to ALS/FTD pathogenes

How do ALS-associated OPTN mutations mechanistically disrupt Rab8a binding and c

What molecular mechanisms determine whether reactive astrocytes adopt neurotoxic

What molecular mechanisms enable functional recovery and muscle re-innervation a

What signals trigger microglia to specifically recognize and phagocytose LC axon

How do oligodendrocytes initiate neuroinflammation in PD when microglia are trad

What molecular mechanisms underlie Atremorine's dramatic dopamine enhancement in

How does PIKFYVE inhibition activate unconventional protein clearance via exocyt

Why have anti-Aβ clinical trials failed despite the established role of Aβ in AD

Can biased TREM2 agonists selectively activate DAP12-SYK-PI3K without triggering

What is the temporal sequence of sleep disruption versus amyloid-beta accumulati

What are the optimal timing windows for TREM2 agonism vs antagonism across disea

Which neural cell types exhibit the most pronounced gene expression alterations

Do transferred mitochondria from diseased astrocytes carry pathological damage t

Can pathological vs physiological C1q tagging be distinguished at the molecular

Which specific post-translational modifications create druggable epitopes unique

Which specific post-translational modifications distinguish pathological from ph

What evidence supports Cdk5 activation as THE primary cause of AD versus other e

Are autophagy-lysosome defects primary drivers or downstream consequences in spo

What physicochemical properties determine selective protein recruitment vs exclu

Which specific post-translational modifications on pathological tau create drugg

Related Papers (20)