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entity

PLASMA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PLASMA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3Connections
13Hypotheses
0Analyses
0Outgoing
3Incoming
0Experiments
0Debates

No AI portrait yet

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Plasma α-Synuclein Aggregation Seeding Activity as Biomarker — NCT07498686

clinical · 1461 words
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Outgoing (0)

TargetRelationTypeStr
No outgoing edges

Incoming (3)

SourceRelationTypeStr
Strem2associated_withprotein0.90
STREM2biomarker_forprotein0.90
IL23Rexpressed_inprotein0.90

Targeting Hypotheses (13)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Plasma NfL Elevation Secondary to BBB-Associated Transport D 0.940 - What blood-brain barrier permeability ch
CSF/Plasma AQP4 Polarization Index as a Novel Biomarker of A 0.705 - What blood-brain barrier permeability ch
Plasma Claudin-5 Proteolytic Fragments Distinguish Paracellu 0.705 - What blood-brain barrier permeability ch
Plasma D-Dimer Elevation Reflects Fibrinogen Leakage and Sec 0.685 - What blood-brain barrier permeability ch
Neurovascular Permeability Score (NVPS): Composite Plasma + 0.600 - Blood-brain barrier permeability changes
Complement C1q Suppression as Mechanism Linking Exercise Pla 0.560 neurodegeneration What are the specific circulating factor
Plasma NfL Elevation Secondary to BBB-Associated Transport D 0.485 - What blood-brain barrier permeability ch
Plasma TREM2 Ectodomain Glycosylation Pattern as Therapeutic 0.427 biomarkers What biomarkers can reliably detect micr
Dynamic Plasma Exosome-Derived Multi-Analyte Panel Combining 0.389 biomarkers What biomarkers can reliably detect micr
Plasma TREM2 Ectodomain Glycosylation Patterns as Microglial 0.380 biomarkers What biomarkers can reliably detect micr
plasma LPS-binding protein separates causal from compensator 0.346 neurodegeneration How does gut microbiome dysbiosis contri
plasma GFAP separates causal from compensatory states in: Bl 0.346 neurodegeneration Blood-brain barrier permeability changes
Plasma p-tau217-Triggered Exosome Dosing Maximizes lncRNA-00 0.323 molecular-neurobiology How does lncRNA-0021 achieve sequence-sp

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PLASMA in their description or question text

Complement C1q Suppression as Mechanism Linking Exercise Plasma to PV Interneuro

Score: 0.560 · neurodegeneration · 2026-04-14

## Mechanistic Overview Complement C1q Suppression as Mechanism Linking Exercise Plasma to PV Interneuron Protection sta

Plasma NfL Elevation Secondary to BBB-Associated Transport Dysfunction Enables L

Score: 0.485 · unknown disease · 2026-04-26

Neurofilament light chain (NfL) is released from damaged neurofilaments into the extracellular space, flowing into CSF a

Plasma TREM2 Ectodomain Glycosylation Pattern as Therapeutic Response Predictor

Score: 0.427 · biomarkers · 2026-04-26

Site-specific glycosylation patterns on circulating TREM2 ectodomain fragments reflect the metabolic state and activatio

Dynamic Plasma Exosome-Derived Multi-Analyte Panel Combining YKL-40, sTREM2, and

Score: 0.389 · biomarkers · 2026-04-26

This hypothesis proposes that plasma-derived exosomes carrying YKL-40, sTREM2, and neurogranin provide a superior biomar

Plasma TREM2 Ectodomain Glycosylation Patterns as Microglial Senescence Biomarke

Score: 0.380 · biomarkers · 2026-04-27

Site-specific glycosylation patterns on circulating TREM2 ectodomain fragments distinguish senescent from activated micr

plasma LPS-binding protein separates causal from compensatory states in: How doe

Score: 0.346 · neurodegeneration · 2026-04-26

A longitudinal biomarker panel centered on plasma LPS-binding protein can distinguish harmful mechanisms from protective

plasma GFAP separates causal from compensatory states in: Blood-brain barrier pe

Score: 0.346 · neurodegeneration · 2026-04-26

A longitudinal biomarker panel centered on plasma GFAP can distinguish harmful mechanisms from protective adaptation. Th

Plasma p-tau217-Triggered Exosome Dosing Maximizes lncRNA-0021 Therapeutic Windo

Score: 0.323 · molecular-neurobiology · 2026-04-17

## Mechanistic Overview Plasma p-tau217-Triggered Exosome Dosing Maximizes lncRNA-0021 Therapeutic Window in AD starts f
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