concept

STREM2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STREM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

65Connections

6Hypotheses

9Analyses

47Outgoing

18Incoming

1Experiments

13Debates

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💡 Concept Info

Name	STREM2
Key Genes/Proteins	TREM2
Related Diseases	Neural Injury, Neuromyelitis Optica Spectrum Disorders, NMOSD
Related Pathways	Nfkb

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

sTREM2 (Soluble TREM2) - Microglial Biomarker

biomarker · 1043 words

→

Pathway Diagram

graph TD
    STREM2["STREM2"]
    STREM2 -.biomarker for.-> Microglial_Activation["Microglial Activation"]
    STREM2 -->|"risk_factor_for"| Neuromyelitis_Optica_Spectrum_["Neuromyelitis Optica Spectrum Disorders"]
    STREM2 -->|"involved_in"| Proteolytic_Shedding["Proteolytic Shedding"]
    STREM2 -.biomarker for.-> Alzheimer_s_disease["Alzheimer's disease"]
    STREM2 -->|"correlates_with"| Neural_Injury["Neural Injury"]
    STREM2 -.biomarker for.-> Alzheimer_s_Disease["Alzheimer's Disease"]
    STREM2 -->|"upregulates"| Myelin_Debris_Phagocytosis["Myelin Debris Phagocytosis"]
    STREM2 -->|"downregulates"| Lipid_Metabolism["Lipid Metabolism"]

Outgoing (47)

Target	Relation	Type	Str
Alzheimer's Disease	associated_with	disease	0.95
ALZHEIMER'S DISEASE	associated_with	disease	0.95
Alzheimer'S Disease	associated_with	disease	0.95
Microglial Activation	biomarker_for	process	0.93
Total Tau	correlates_with	biomarker	0.92
Neurofilament Light	correlates_with	biomarker	0.92
Neuromyelitis Optica Spectrum Disorders	risk_factor_for	disease	0.92
Phospho-Tau	correlates_with	biomarker	0.92
Proteolytic Shedding	involved_in	process	0.90
Early-Stage Alzheimer'S Disease	associated_with	disease	0.90
PLASMA	biomarker_for	biofluid	0.90
TREM2	associated_with	protein	0.90
Cerebrospinal Fluid	associated_with	biomarker	0.90
Plasma	associated_with	biomarker	0.90
Microglia Activity	biomarker_for	process	0.90
cerebrospinal fluid	biomarker_for	biofluid	0.90
Neuroinflammation	associated_with	process	0.90
microglial priming state	biomarker_for	phenotype	0.90
Alzheimer's disease	biomarker_for	disease	0.90
Neural Injury	correlates_with	phenotype	0.88
Alzheimer's Disease	biomarker_for	disease	0.88
Neuronal Injury	associated_with	process	0.88
Myelin Debris Phagocytosis	upregulates	process	0.87
Lipid Metabolism	downregulates	process	0.86
Alzheimer'S Disease	biomarker_for	disease	0.85
Nfkb	activates	pathway	0.85
Glycolysis	upregulates	process	0.85
NEUROINFLAMMATION	biomarker_for	process	0.85
Alzheimer'S Disease	therapeutic_target	disease	0.85
NMOSD	biomarker_for	disease	0.80
Neurodegenerative Disease	biomarker_for	disease	0.80
Neurodegenerative Disease	biomarker_for	disease	0.80
MICROGLIA	triggers_dysfunction	cell_type	0.80
microglial dysfunction	triggers	process	0.80
early Alzheimer's disease	biomarker_for	disease	0.70
Tau Pathology	biomarker_for	phenotype	0.70
microglial_activation	biomarker_for	phenotype	0.70
early symptomatic AD	biomarker_for	disease	0.70
brain TREM2 expression	biomarker_for	process	0.70
microglial burden	biomarker_for	process	0.70
Alzheimer disease	biomarker_for	disease	0.70
Alzheimer's disease stage	biomarker_for	disease	0.70
microglial proliferation	regulates	process	0.70
TREM2-agonist trials	biomarker_for	process	0.70
microglial activation state	biomarker_for	process	0.70
AD progression	biomarker_for	disease	0.70
Early AD	associated_with	disease	0.70

Incoming (18)

Source	Relation	Type	Str
TREM2	expressed_in	gene	0.95
37865646	deactivates	paper	0.90
30911003	exerts protective role against	paper	0.90
30911003	reduces	paper	0.90
30911003	rescues	paper	0.90
30911003	enhances	paper	0.90
37865646	binds to	paper	0.90
37865646	induces	paper	0.90
39817909	propagates	paper	0.90
38001539	mediates	paper	0.90
TREM2	produces	gene	0.90
ADAM10	activates	protein	0.90
Age	upregulates	phenotype	0.88
ADAM10	causes	gene	0.70
ADAM17	causes	gene	0.70
39748415	did not show significant mediation effects on	paper	0.60
38001539	mediating	paper	0.60
38001539	is mediating	paper	0.60

Targeting Hypotheses (6)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Integrated Multi-Analyte CSF Panel Combining YKL-40, sTREM2,	0.807	biomarkers	What biomarkers can reliably detect micr
CSF sTREM2 as Pharmacodynamic Biomarker for Therapeutic Wind	0.801	neuroimmunology	TREM2 in Alzheimer's Disease: Mechanisms
sTREM2 as Biomarker of Cystatin-C Therapeutic Efficacy	0.757	neurodegeneration	Does the cancer-cystatin-C-TREM2 pathway
Soluble TREM2 (sTREM2) as Therapeutic Mimic — Decoupling Pha	0.714	alzheimers	TREM2 agonism vs antagonism in DAM micro
Dynamic Plasma Exosome-Derived Multi-Analyte Panel Combining	0.389	biomarkers	What biomarkers can reliably detect micr

Dynamic Blood-Based Exosome Panel for Real-Time Neuroinflamm	0.380	biomarkers	What biomarkers can reliably detect micr

Mentioning Analyses (9)

Scientific analyses that reference this entity

Multi-modal Biomarker Panel Design for Early AD Detection

neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.579

Gene Co-expression Network Analysis of AD Progression Modules

neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.844

What is the temporal sequence of TREM2 signaling transition from protective to i

neuroimmunology | 2026-04-15 | 1 hypotheses Top: 0.670

What are the molecular signatures that distinguish protective vs. harmful microg

neurodegeneration | 2026-04-12 | 0 hypotheses

Which specific aging-related gene expression changes in mouse brain predict huma

neurodegeneration | 2026-04-11 | 0 hypotheses

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Autophagy receptor identification for stress granule elimination	exploratory	neurodegenerative diseases	0.900	0.00	cultured cells under arsenite	proposed	N/A

Related Papers (4)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Obesity-induced pyroptotic adipocyte death leads to TREM2-dependent macrophage d [PMID:41509917]	Choi C, Lee J, Park G, Namgoong S, Lee Y	iScience	2026
Neurodegeneration and demyelination in multiple sclerosis. [PMID:38889714]	Garton T, Gadani SP, Gill AJ, Calabresi	Neuron	2024
STING orchestrates the neuronal inflammatory stress response in multiple scleros [PMID:38878778]	Woo MS, Mayer C, Binkle-Ladisch L, Sonne	Cell	2024
Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration. [PMID:36917977]	Neel DV, Basu H, Gunner G, Bergstresser	Neuron	2023

Debates (13)

Multi-agent debates referencing this entity

Debate: TREM2 R47H Metabolic Lock-in at Cholesterol Ester Accumulation

closed · Rounds: 4 · Score: 0.59 · 2026-04-27

The debate focused on therapeutic targets but did not address how to identify pa

closed · Rounds: 4 · Score: 0.75 · 2026-04-22

The debate proposed biphasic TREM2 modulation but couldn't define when to switch

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

The debate proposed temporal TREM2 modulation but couldn't define when to switch

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

What co-expression modules are shared and unique across brain regions in AD, and

closed · Rounds: 4 · Score: 0.70 · 2026-04-21

Can a multi-modal biomarker panel combining plasma proteins, neuroimaging featur

closed · Rounds: 4 · Score: 0.70 · 2026-04-21

The debate aimed to cross-reference Allen Aging Mouse Brain Atlas data with huma

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

The debate transcript shows incomplete information exchange, suggesting this fun

closed · Rounds: 4 · Score: 0.49 · 2026-04-18

Should clinical practice adopt multi-modal biomarker panels now, or wait for sin

closed · Rounds: 4 · Score: 0.70 · 2026-04-16

Is TYROBP a genuine therapeutic target in AD, or is it a downstream marker of mi