Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about STREM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | STREM2 |
| Key Genes/Proteins | TREM2 |
| Related Diseases | Neuromyelitis Optica Spectrum Disorders, Neural Injury, NMOSD |
| Related Pathways | Nfkb |
| Linked Hypotheses | 2 hypotheses |
Knowledge base pages for this entity
graph TD
STREM2["STREM2"]
STREM2 -.biomarker for.-> Microglial_Activation["Microglial Activation"]
STREM2 -->|"risk_factor_for"| Neuromyelitis_Optica_Spectrum_["Neuromyelitis Optica Spectrum Disorders"]
STREM2 -->|"involved_in"| Proteolytic_Shedding["Proteolytic Shedding"]
STREM2 -.biomarker for.-> Alzheimer_s_disease["Alzheimer's disease"]
STREM2 -->|"correlates_with"| Neural_Injury["Neural Injury"]
STREM2 -.biomarker for.-> Alzheimer_s_Disease["Alzheimer's Disease"]
STREM2 -->|"upregulates"| Myelin_Debris_Phagocytosis["Myelin Debris Phagocytosis"]
STREM2 -->|"downregulates"| Lipid_Metabolism["Lipid Metabolism"]| Target | Relation | Type | Str |
|---|---|---|---|
| Neuromyelitis Optica Spectrum Disorders | risk_factor_for | disease | 0.92 |
| Neuroinflammation | associated_with | process | 0.90 |
| cerebrospinal fluid | biomarker_for | biofluid | 0.90 |
| PLASMA | biomarker_for | biofluid | 0.90 |
| Neural Injury | correlates_with | phenotype | 0.88 |
| Myelin Debris Phagocytosis | upregulates | process | 0.87 |
| Lipid Metabolism | downregulates | process | 0.86 |
| Nfkb | activates | pathway | 0.85 |
| Glycolysis | upregulates | process | 0.85 |
| MICROGLIA | triggers_dysfunction | cell_type | 0.80 |
| microglial dysfunction | triggers | process | 0.80 |
| NMOSD | biomarker_for | disease | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TREM2 | produces | gene | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| CSF sTREM2 as Pharmacodynamic Biomarker for Therapeutic Wind | 0.674 | neuroimmunology | What is the temporal sequence of TREM2 s |
| Soluble TREM2 (sTREM2) as Therapeutic Mimic — Decoupling Pha | 0.452 | Alzheimer's disease | TREM2 agonism vs antagonism in DAM micro |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Obesity-induced pyroptotic adipocyte death leads to TREM2-dependent macrophage d [PMID:41509917] | Choi C, Lee J, Park G, Namgoong S, Lee Y | iScience | 2026 | 0 |