protein

NF-ΚB P65

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NF-ΚB P65: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

28Connections

0Hypotheses

2Analyses

12Outgoing

16Incoming

0Experiments

3Debates

Summary

Page for NF-κB p65 Protein

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🔬 Protein Info

Gene Symbol	NF
Full Name	ΚB P65
Function	Nf Κb P105 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
GeneCards	NF
Human Protein Atlas	NF
Interactions	AMPK, EAAT2, IL-18, NRF2, Proteins, SIRT1
KG Connections	22 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

flowchart TD
    N0["NF-KappaB P65"]
    N1["IL-18"]
    N0 -->|"activates"| N1
    N2["AMPK"]
    N0 -->|"activates"| N2
    N3["NF-kappaB"]
    N0 -->|"activates"| N3
    N4["aging"]
    N0 -->|"inhibits"| N4
    N0 -->|"inhibits"| N2
    N0 -->|"inhibits"| N3
    N0 -->|"expressed in"| N3
    N5["BCL-2"]
    N0 -->|"expressed in"| N5
    N6["TNF-alpha"]
    N0 -->|"expressed in"| N6
    N7["CYTOKINES"]
    N0 -->|"inhibits"| N7
    N8["Proteins"]
    N0 -->|"inhibits"| N8
    N9["SIRT1"]
    N9 -->|"activates"| N0
    N10["NRF2"]
    N10 -->|"activates"| N0
    N9 -->|"inhibits"| N0

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 protein
    class N2 protein
    class N5 protein
    class N8 protein
    class N9 gene
    class N10 gene

Outgoing (12)

Target	Relation	Type	Str
CCL2	regulates	protein	0.93
IL-18	activates	protein	0.50
AMPK	activates	protein	0.50
NF-κB	activates	concept	0.50
aging	inhibits	phenotype	0.50
AMPK	inhibits	protein	0.50
NF-κB	inhibits	concept	0.50
NF-κB	expressed_in	concept	0.50
BCL-2	expressed_in	protein	0.50
TNF-α	expressed_in	concept	0.50
CYTOKINES	inhibits	concept	0.50
Proteins	inhibits	protein	0.50

Incoming (16)

Source	Relation	Type	Str
SIRT1	deacetylates	protein	0.90
39427196	directly interacted with	paper	0.90
AMPK/SIRT1 Signaling Pathway	downregulates	pathway	0.85
PLCB3	activates	gene	0.80
HDAC3	modulates	protein	0.70
SIRT1	activates	gene	0.50
NRF2	activates	gene	0.50
SIRT1	inhibits	gene	0.50
NRF2	inhibits	gene	0.50
GFAP	expressed_in	gene	0.50
CYTC	expressed_in	gene	0.50
CASPASE-3	expressed_in	protein	0.50
IL-6	expressed_in	protein	0.50
CASPASE-9	expressed_in	protein	0.50
IL-1Β	expressed_in	protein	0.50
EAAT2	activates	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

What molecular mechanisms determine whether reactive astrocytes adopt neurotoxic

neuroinflammation | 2026-04-14 | 2 hypotheses Top: 0.651

Investigate mechanisms of epigenetic reprogramming in aging neurons

neurodegeneration | 2026-04-10 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Investigate mechanisms of epigenetic reprogramming in aging neurons [TARGET_ART

closed · Rounds: 0 · Score: 0.50 · 2026-04-21

Investigate mechanisms of epigenetic reprogramming in aging neurons

closed · Rounds: 0 · Score: 0.56 · 2026-04-21

The abstract describes astrocyte phenotypic heterogeneity (A1/A2) but doesn't ex

closed · Rounds: 4 · Score: 0.66 · 2026-04-15

Related Research

Hypotheses and analyses mentioning NF-ΚB P65 in their description or question text

No additional research found