gene

PNMT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PNMT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Enzyme converting norepinephrine to epinephrine

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🧬 Gene Info

Gene Symbol	PNMT
Chromosome	17q21.2
Protein Type	Gene
Function	PNMT catalyzes the methylation of norepinephrine to produce epinephrine
Primary Expression	the adrenal medulla and in certain brain regions, particularly the locus coeruleus
Molecular Weight	30 kDa
Amino Acids	291 aa
GeneCards	PNMT
Human Protein Atlas	PNMT
Gene	PNMT (chromosome 17q21.2)
Protein Class	Methyltransferase (EC 2.1.1.28)
Protein Size	291 amino acids
Primary Localization	Cytoplasm of adrenal medulla chromaffin cells, locus coeruleus neurons
Cofactor Requirement	S-adenosylmethionine (SAM)
Disease Associations	Stress disorders, cardiovascular disease, neurodegenerative conditions
Associated Diseases	Stress disorders, cardiovascular disease, neurodegenerative conditions
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PNMT["PNMT"]
    neurodegeneration["neurodegeneration"]
    PNMT -->|"implicated_in"| neurodegeneration
    style PNMT fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning PNMT in their description or question text

No additional research found