Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about POLD3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
POLD3 encodes the p66 subunit of DNA polymerase delta, involved in DNA replication and repair with implications for neurodegeneration
| Gene Symbol | POLD3 |
| Full Name | DNA Polymerase Delta Subunit 3 |
| Chromosome | 16q24.1 |
| Function | ### DNA Polymerase Delta Complex |
| Molecular Weight | 124 kDa |
| Amino Acids | 571 aa |
| UniProt ID | [Q9ZJM2](https://www.uniprot.org/uniprot/Q9ZJM2) |
| Ensembl ID | ENSG00000175482 |
| OMIM | 608412 |
| GeneCards | POLD3 |
| Human Protein Atlas | POLD3 |
| High metabolic demand | Neurons have high oxidative phosphorylation, producing reactive oxygen species (ROS) that cause oxidative DNA damage |
| Non-dividing state | Unlike other cell types, neurons cannot use cell division to dilute accumulated DNA damage |
| Long lifespan | Human neurons must maintain genome integrity for decades |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
POLD3["POLD3"]
neurodegeneration["neurodegeneration"]
POLD3 -->|"implicated_in"| neurodegeneration
style POLD3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| No outgoing edges | |||
| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity