Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about POMT2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Protein O-Mannosyltransferase 2 - catalyzes O-mannosylation critical for alpha-dystroglycan and neuronal development
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| Gene Symbol | POMT2 |
| Aliases | Protein O-Mannosyltransferase 2 |
| Chromosome | 14q24.3 |
| Protein Type | Transferase |
| Function | is an endoplasmic reticulum-resident glycosyltransferase that catalyzes the critical first step in the O-mannosylation of proteins. |
| Molecular Weight | 85 kDa |
| Amino Acids | 650 aa |
| GeneCards | POMT2 |
| Human Protein Atlas | POMT2 |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
POMT2["POMT2"]
neurodegeneration["neurodegeneration"]
POMT2 -->|"implicated_in"| neurodegeneration
style POMT2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning POMT2 in their description or question text
No additional research found