gene

PPP1R1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPP1R1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

PPP1R1A encodes DARPP-32, a neuronal phosphoprotein that regulates protein phosphatase 1 and dopaminergic signaling in the striatum.

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🧬 Gene Info

Gene Symbol	PPP1R1A
Primary Expression	the striatum, particularly in the:
Molecular Weight	32 kDa
Amino Acids	204 aa
Ensembl ID	ENSG00000132664
GeneCards	PPP1R1A
Human Protein Atlas	PPP1R1A
N-terminal domain	Contains Thr34 phosphorylation site, the primary functional phosphorylation site
Central region	Houses additional regulatory phosphorylation sites (Thr75, Ser102, Ser130)
C-terminal domain	Involved in protein-protein interactions
Associated Diseases	Parkinson's disease, Alzheimer's disease
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PPP1R1A (DARPP-32)

gene · 1628 words

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Pathway Diagram

graph TD
    PPP1R1A["PPP1R1A"]
    neurodegeneration["neurodegeneration"]
    PPP1R1A -->|"implicated_in"| neurodegeneration
    style PPP1R1A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PPP1R1A in their description or question text

No additional research found