gene

PPP1R9A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPP1R9A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Protein Phosphatase 1 Regulatory Subunit 9A (Neurabin-1) regulates synaptic function and plasticity.

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🧬 Gene Info

Gene Symbol	PPP1R9A
Full Name	Protein Phosphatase 1 Regulatory Subunit 9A
Aliases	Neurabin-1
Chromosome	7q21.3
Protein Type	Scaffold Protein
Primary Expression	neurons, not in glia - Postsynaptic localization: Concentrated in dendritic spines and postsynaptic densities - Brain region specificity: High
Pathways	Synaptic Plasticity
UniProt ID	[Q9Y5X4](https://www.uniprot.org/uniprot/Q9Y5X4)
GeneCards	PPP1R9A
Human Protein Atlas	PPP1R9A
N-terminal domain	Contains an actin-binding site that targets the protein to dendritic spines
PP1-binding domain (RVXF motif)	Conserved sequence that recruits protein phosphatase 1
PDZ domain	Enables interactions with other synaptic proteins and receptors
C-terminal coiled-coil domain	Mediates dimerization and protein-protein interactions
AMPA receptor subunits	Regulates receptor trafficking and conductance
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PPP1R9A Gene

gene · 1500 words

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Pathway Diagram

graph TD
    PPP1R9A["PPP1R9A"]
    neurodegeneration["neurodegeneration"]
    PPP1R9A -->|"implicated_in"| neurodegeneration
    style PPP1R9A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning PPP1R9A in their description or question text

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