Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PRIMPOL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
PRIMPOL: DNA primase and translesion polymerase with roles in mitochondrial DNA replication, oxidative stress response, and neurodegenerative disease
| Gene Symbol | PRIMPOL |
| Full Name | DNA Primase/Polymerase |
| Chromosome | 9q34.2 |
| Protein Type | Enzyme |
| Function | is a unique bifunctional enzyme belonging to the archaeo-eukaryotic primase (AEP) family. |
| Molecular Weight | 58 kDa |
| Amino Acids | 517 aa |
| Exons | 14 |
| UniProt ID | [Q8IY92](https://www.uniprot.org/uniprot/Q8IY92) |
| Ensembl ID | ENSG00000146859 |
| GeneCards | PRIMPOL |
| Human Protein Atlas | PRIMPOL |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, ALS |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
PRIMPOL["PRIMPOL"]
neurodegeneration["neurodegeneration"]
PRIMPOL -->|"implicated_in"| neurodegeneration
style PRIMPOL fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||