entity

PROC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PROC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

13Hypotheses

0Analyses

1Outgoing

0Incoming

0Experiments

0Debates

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Outgoing (1)

Target	Relation	Type	Str
Sepsis	biomarker_for	disease	0.90

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (13)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
RBM45 Liquid-Liquid Phase Separation Dominance Hijacks RNA P	0.868	als	-
MATR3 Nuclear Body Disruption Impairs RNA Processing Hubs an	0.801	als	-
Endosomal trafficking defects are the common upstream lesion	0.730	neurodegeneration	What determines the temporal sequence of
FUS Phase Separation Dominance in FTD-TDP: Aberrant Condensa	0.683	frontotemporal-dementia	-
Dysregulated G3BP1 Signaling Impairs Local Translation in Ne	0.580	neurodegeneration	How do disease-associated mutations in G

Cdk5/p25-PSD-95 Phosphorylation Disrupts Synaptic Scaffoldin	0.455	neurodegeneration	Quantitative proteomics of the aging syn
Synaptic Vesicle Protein Phosphorylation Reprograms Release	0.455	neurodegeneration	Quantitative proteomics of the aging syn
Dicer-Processed siRNA-Mediated Transcript Silencing	0.405	-	How does the intron-retained RNA isoform
Cathepsin-Dependent Processing of Pro-Drug Enzymes	0.400	neurodegeneration	How does controlled lysosomal membrane p
Temporal Processing Enhancement Hypothesis	0.000	-	Unable to extract research questions - t
APP Processing Compartmentalization Therapeutics	0.000	-	Lipid raft composition changes in synapt
Amyloid Precursor Protein Processing Modulation via Bacteria	0.000	-	Gut-Brain Axis Therapeutics for Alzheime
Mitochondrial RNA Processing Enhancement	0.000	-	RNA binding protein dysregulation across

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PROC in their description or question text

Cdk5/p25-PSD-95 Phosphorylation Disrupts Synaptic Scaffolding and Shifts APP Pro

Score: 0.455 · neurodegeneration · 2026-04-27

Age-dependent p35-to-p25 cleavage activates Cdk5, which phosphorylates PSD-95 S561, disrupting AMPA/NMDA receptor anchor

Synaptic Vesicle Protein Phosphorylation Reprograms Release Probability and Inte

Score: 0.455 · neurodegeneration · 2026-04-27

Synaptic activity-dependent phosphorylation of synapsin-1 by CamKII and calcineurin dynamically regulates vesicle mobili

Dicer-Processed siRNA-Mediated Transcript Silencing

Score: 0.405 · unknown disease · 2026-04-26

Retained intronic sequences contain inverted repeat elements forming long dsRNA structures recognized by Dicer, which cl

Cathepsin-Dependent Processing of Pro-Drug Enzymes

Score: 0.400 · neurodegeneration · 2026-04-21

## Mechanistic Overview Cathepsin-Dependent Processing of Pro-Drug Enzymes starts from the claim that modulating CTSD, U

Temporal Processing Enhancement Hypothesis

Score: 0.000 · unknown disease · 2026-04-28

Targeted modulation of gamma-aminobutyric acid interneurons improves temporal sequencing abilities crucial for tracking

APP Processing Compartmentalization Therapeutics

Score: 0.000 · unknown disease · 2026-04-28

Selective targeting of secretase localization to shift APP processing from amyloidogenic to non-amyloidogenic pathways

Amyloid Precursor Protein Processing Modulation via Bacterial Enzyme Delivery

Score: 0.000 · unknown disease · 2026-04-28

Engineered gut bacteria producing α-secretase-like enzymes or β-secretase inhibitors can be delivered orally to influenc

Mitochondrial RNA Processing Enhancement

Score: 0.000 · unknown disease · 2026-04-28

Since RBP dysfunction affects mitochondrial RNA metabolism across these diseases, targeted enhancement of mitochondrial