protein

PROGRANULIN_PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PROGRANULIN_PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

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0Experiments

Summary

Progranulin Protein (PGRN)

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🔬 Protein Info

Gene Symbol	GRN
Full Name	Progranulin
Aliases	PROGRANULIN_PROTEIN
Chromosome	17q21.31.
Function	is a secreted glycoprotein encoded by the GRN gene that functions as a crucial regulator of neuronal survival, lysosomal function, immune response, and synaptic plasticity.
Primary Expression	Neurons, Microglia, Macrophages, Epithelial cells
Subcellular Localization	Secreted, Lysosomes, Cytoplasm
Molecular Weight	63.5 kDa (full-length); secreted fragments: 6-25 kDa
Amino Acids	593 aa
UniProt ID	P28799
GeneCards	GRN
Human Protein Atlas	GRN
Associated Diseases	ALS, Dementia, FRONTOTEMPORAL DEMENTIA, Ftd
Interactions	CX3CR1, CXCL10, BDNF, FGF23, PLAU, VIM
KG Connections	328 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: PROGRANULIN_PROTEIN — AlphaFold P28799 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PROGRANULIN_PROTEIN["PROGRANULIN_PROTEIN"]
    neurodegeneration["neurodegeneration"]
    PROGRANULIN_PROTEIN -->|"implicated_in"| neurodegeneration
    style PROGRANULIN_PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PROGRANULIN_PROTEIN

Understanding Entity Pages

Summary

Wiki Pages (21)