disease

Frontotemporal Dementia

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Frontotemporal Dementia: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2122Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Frontotemporal Dementia is a disease characterized by neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with Amyotrophic Lateral Sclerosis, Multisystem Proteinopathy. Connected to 304 entities in the SciDEX knowledge graph.

View on Wiki →

Disease Info

Associated Genes	UNC13A, HNRNPA1, HNRNPA2B1, OPTN, SQSTM1, TIA1, VALOSIN, VCP
Therapeutic Agents	Disease-Modifying Therapies, Gene Therapy Targeting 14-3-3θ-TDP-43 Interaction, Tdp-43-Targeting Gene Therapy, RNA oligonucleotides
KG Connections	819 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Frontotemporal_Dementia["Frontotemporal Dementia"] -->|"interacts"| Autophagy["Autophagy"]
    Frontotemporal_Dementia["Frontotemporal Dementia"] -->|"regulates"| Oxidative_Stress["Oxidative Stress"]
    Frontotemporal_Dementia["Frontotemporal Dementia"] -->|"regulates"| Er_Stress["Er Stress"]
    Frontotemporal_Dementia["Frontotemporal Dementia"] -->|"interacts"| Apoptosis["Apoptosis"]
    Frontotemporal_Dementia["Frontotemporal Dementia"] -->|"interacts"| Cell_Cycle["Cell Cycle"]
    Frontotemporal_Dementia["Frontotemporal Dementia"] -->|"interacts"| Mapk["Mapk"]
    ACTB["ACTB"] -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    BECN1["BECN1"] -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    C9ORF72["C9ORF72"] -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    CALCOCO2["CALCOCO2"] -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    style Frontotemporal_Dementia fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (496)

Target	Relation	Type	Str
Behavioral Disturbances	causes	phenotype	0.95
Frontal Lobe Neurodegeneration	causes	process	0.95
Anterior Temporal Lobe Neurodegeneration	causes	process	0.95
Neurodegeneration	causes	process	0.95
Brain Atrophy	causes	phenotype	0.90
Pre-Symptomatic Stage	associated_with	phenotype	0.90
MAPT	associated_with	gene	0.85
Anterior Temporal Lobe	expressed_in	cell_type	0.85
Frontal Lobe	expressed_in	cell_type	0.85
Movement Disorders	associated_with	disease	0.85
TARDBP	associated_with	protein	0.85
Autophagy	interacts_with	pathway	0.55
Oxidative Stress	regulates	pathway	0.55
Er Stress	regulates	pathway	0.55
Apoptosis	interacts_with	pathway	0.55
Cell Cycle	interacts_with	pathway	0.55
Mapk	interacts_with	pathway	0.55
Mitophagy	therapeutic_target	pathway	0.55
Protein Aggregation	associated_with	pathway	0.55
Autophagy	activates	pathway	0.55
Mtor	activates	pathway	0.55
Proteasome	activates	pathway	0.55
Ubiquitin-Proteasome	activates	pathway	0.55
Unfolded Protein Response	activates	pathway	0.55
Autophagy	associated_with	pathway	0.55
Mtor	associated_with	pathway	0.55
Complement	regulates	pathway	0.55
Amyloid	contributes_to	pathway	0.55
Mitophagy	interacts_with	pathway	0.55
Tdp-43	activates	pathway	0.55
Tdp-43	associated_with	pathway	0.55
Sod1	inhibits	pathway	0.55
Sod1	contributes_to	pathway	0.55
Tdp-43	causes	pathway	0.55
Sod1	causes	pathway	0.55
Synaptic Vesicle	interacts_with	pathway	0.55
Amyloid	biomarker_for	pathway	0.55
Autophagy	causes	pathway	0.55
Autophagy	therapeutic_target	pathway	0.55
Phagocytosis	therapeutic_target	pathway	0.55
Protein Aggregation	regulates	pathway	0.55
Akt	causes	pathway	0.55
Protein Aggregation	activates	pathway	0.55
Oxidative Stress	activates	pathway	0.55
Mtor	therapeutic_target	pathway	0.55
Immune Response	activates	pathway	0.55
Er Stress	inhibits	pathway	0.55
Necroptosis	causes	pathway	0.55
Phagocytosis	activates	pathway	0.55
Jak-Stat	activates	pathway	0.55

Incoming (1626)

Source	Relation	Type	Str
TBK1	associated_with	gene	0.95
TDP43	associated_with	protein	0.95
C9ORF72	risk_factor_for	gene	0.95
TDP-43	causes	protein	0.95
TBK1	risk_factor_for	gene	0.95
C9orf72 Hexanucleotide Repeat Expansion	causes	biomarker	0.95
GRN	risk_factor_for	gene	0.95
MAPT	risk_factor_for	gene	0.95
Tau	biomarker_for	protein	0.95
SQSTM1	biomarker_for	protein	0.95
Synaptic Dysfunction	contributes_to	phenotype	0.95
Cerebral Perfusion	biomarker_for	biomarker	0.92
Amyotrophic Lateral Sclerosis	associated_with	disease	0.90
Tau Aggregation	associated_with	process	0.90
Autophagy	involved_in	process	0.90
TAU	associated_with	protein	0.90
Innate Immune Activation	contributes_to	process	0.90
Frontotemporal Phenotype	associated_with	phenotype	0.90
Innate Immune Activation	associated_with	process	0.90
UNC13A	risk_factor_for	gene	0.90
TDP-43	involved_in	protein	0.90
Tdp-43-Targeting Gene Therapy	treats	drug	0.90
STING	associated_with	protein	0.90
C9ORF72 Hexanucleotide Repeat Expansion	risk_factor_for	biomarker	0.90
Biomarker	biomarker_for	biomarker	0.90
Neurodegeneration	involved_in	process	0.90
CHMP2B	risk_factor_for	gene	0.90
NOTCH2NLC	associated_with	gene	0.90
Cryptic Splicing	biomarker_for	process	0.90
TDP43	implicated_in	protein	0.90
CHMP2BIn5	drives	protein	0.90
Gene Therapy Targeting 14-3-3θ-TDP-43 Interaction	treats	drug	0.88
TDP-43	biomarker_for	protein	0.88
Microglial Synapse Elimination	contributes_to	process	0.85
NPTX2	biomarker_for	protein	0.85
Multisystem Proteinopathy	associated_with	disease	0.85
Reduced NPTX2 Concentrations	biomarker_for	biomarker	0.85
GSDME	associated_with	protein	0.85
Impaired Stress Granule Disassembly	associated_with	phenotype	0.85
Vesicle Trafficking	involved_in	process	0.85
Protein Deposition	contributes_to	process	0.85
Language Deficits	biomarker_for	phenotype	0.85
Behavioral Changes	biomarker_for	phenotype	0.85
Reducing Stress Granule Formation	contributes_to	process	0.85
Left Thalamus Hypoperfusion	biomarker_for	phenotype	0.85
Mutation Carriers	risk_factor_for	biomarker	0.85
Stress Granule Formation	protects_against	process	0.85
YWHAQ	mediates	protein	0.85
GGGGCC Hexanucleotide Repeat Expansion	biomarker_for	biomarker	0.85
Tau Aggregation Propagation	involved_in	process	0.85

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Frontotemporal Dementia

Understanding Entity Pages

Summary

Wiki Pages (20)

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

primary-progressive-aphasia

calcium-dysregulation-comparison

Corticobasal Degeneration (CBD)

Therapeutics

Neurons — Cell Type Hierarchy