protein

PARVALBUMIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PARVALBUMIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

4Connections

4Hypotheses

1Analyses

3Outgoing

1Incoming

0Experiments

18Debates

Summary

Parvalbumin (PVALB) Protein

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🔬 Protein Info

Gene Symbol	PARVALBUMIN
Molecular Weight	~11.5 kDa
GeneCards	PARVALBUMIN
Human Protein Atlas	PARVALBUMIN
KG Connections	1 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    PARVALBUMIN["PARVALBUMIN"]
    DEPRESSION["DEPRESSION"]
    PARVALBUMIN -->|"regulates"| DEPRESSION
    style PARVALBUMIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (3)

Target	Relation	Type	Str
Pv+ Interneuron	expressed_in	cell_type	0.95
fast-spiking interneuron firing	associated_with	phenotype	0.90
DEPRESSION	regulates	disease	0.70

Incoming (1)

Source	Relation	Type	Str
PVALB	encodes	gene	0.90

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop tACS targeting EC-II parvalbumin interneurons to	0.869	alzheimers	Circuit-level neural dynamics in neurode
Parvalbumin Interneuron Vulnerability Links Lactate Transpor	0.656	neurodegeneration	What is the molecular mechanism by which
TYRO3-STAT1 Axis to Preserve Parvalbumin Interneuron Functio	0.506	neuroinflammation	Why do TAM receptors protect against neu
APOE4 astrocytes fail to supply sufficient cholesterol to pa	0.500	neuroscience	APOE4-driven lipid metabolism dysregulat

Mentioning Analyses (1)

Scientific analyses that reference this entity

Circuit-level neural dynamics in neurodegeneration

neuroscience | 2026-04-03 | 73 hypotheses Top: 0.968

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (2)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Targeting Neural Oscillations for Cognitive Enhancement in Alzheimer’s Disease [PMID:40142358]	Federica Palacino, P. Manganotti, A. Ben	{'name': 'Medicina', 'volume':	2025	0
Impact of 40 Hz Transcranial Alternating Current Stimulation on Cerebral Tau Bur [PMID:34958021]	M. Dhaynaut, G. Sprugnoli, D. Cappon	{'name': "Journal of Alzheimer	2021	0