PVALB

Understanding Entity Pages

This page aggregates everything SciDEX knows about PVALB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

PVALB encodes parvalbumin, a calcium-binding protein in fast-spiking GABAergic interneurons. Critical for cortical inhibition, gamma oscillations, and is vulnerable in AD/PD.

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graph TD
    PVALB["<b>PVALB</b>"]
    Thalamo_Amygdala_Signaling(["Thalamo-Amygdala Signaling"])
    PVALB -->|"involved in"| Thalamo_Amygdala_Signaling
    Alzheimer_s_disease{"Alzheimer's disease"}
    PVALB -->|"therapeutic target"| Alzheimer_s_disease
    Neurodegeneration{"Neurodegeneration"}
    PVALB -->|"interacts with"| Neurodegeneration
    PVALB -->|"implicated in"| Alzheimer_s_disease
    NR3C1["NR3C1"]
    PVALB -->|"interacts with"| NR3C1
    NEURODEGENERATION["NEURODEGENERATION"]
    PVALB -->|"interacts with"| NEURODEGENERATION
    TNF["TNF"]
    PVALB -->|"associated with"| TNF
    APP["APP"]
    PVALB -->|"associated with"| APP
    BDNF["BDNF"]
    PVALB -->|"associated with"| BDNF
    DLG4["DLG4"]
    PVALB -->|"associated with"| DLG4
    FKBP5["FKBP5"]
    PVALB -->|"interacts with"| FKBP5
    Amygdala["Amygdala"]
    PVALB -->|"expressed in"| Amygdala
    h_62f9fc90["h-62f9fc90"]
    h_62f9fc90 -->|"therapeutic target"| PVALB
    h_62f9fc90 -->|"targets"| PVALB
    CASP3["CASP3"]
    CASP3 -->|"associated with"| PVALB
    FKBP5 -->|"interacts with"| PVALB
    APP -->|"associated with"| PVALB
    TNF -->|"associated with"| PVALB
    AND["AND"]
    AND -->|"associated with"| PVALB
    DLG4 -->|"associated with"| PVALB
    BDNF -->|"associated with"| PVALB
    NR3C1 -->|"interacts with"| PVALB
    style PVALB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0