gene

RAB28

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAB28: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

RAB28 - RAS-Related Protein involved in synaptic vesicle trafficking, autophagy, and neurodegenerative disease

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🧬 Gene Info

Gene Symbol	RAB28
Full Name	RAS-Related Protein RAB28
Chromosome	4p15.1
Function	encodes a 225 amino acid protein with the characteristic structural features of Rab GTPases.
Molecular Weight	24.5 kDa
Amino Acids	225 aa
UniProt ID	[Q9NPH5](https://www.uniprot.org/uniprot/Q9NPH5)
Ensembl ID	ENSG00000175164
OMIM	612586
GeneCards	RAB28
Human Protein Atlas	RAB28
Palmitoylation	modulates membrane association
Synaptic vesicle biogenesis	Controls vesicle formation from endosomes
Vesicle trafficking	Regulates movement between synaptic compartments
Neurotransmitter release	Coordinates exocytosis timing
Associated Diseases	Parkinson's disease, Alzheimer's disease
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RAB28 Gene

gene · 2301 words

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RAB28 Protein

protein · 658 words

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Pathway Diagram

graph TD
    RAB28["RAB28"]
    neurodegeneration["neurodegeneration"]
    RAB28 -->|"implicated_in"| neurodegeneration
    style RAB28 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning RAB28 in their description or question text

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