gene

RAMP3

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about RAMP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

RAMP3 forms receptor complexes with CALCRL for adrenomedullin and CGRP signaling, with roles in neuroprotection and cerebrovascular function

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🧬 Gene Info

Gene Symbol	RAMP3
Full Name	Receptor Activity Modifying Protein 3
Chromosome	7p13-p12
Function	is a key feature[@buo2019].
Primary Expression	Brain, heart, lung, spleen, endothelium
UniProt ID	[Q9Y5Y9](https://www.uniprot.org/uniprot/Q9Y5Y9)
Ensembl ID	ENSG00000122679
GeneCards	RAMP3
Human Protein Atlas	RAMP3
RAMP1	Forms CGRP receptors when paired with CALCRL
RAMP2	Forms AM receptors with CALCRL (vascular type)
RAMP3	Forms both AM and CGRP receptors with CALCRL
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RAMP3 — Receptor Activity Modifying Protein 3

gene · 1460 words

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Pathway Diagram

graph TD
    RAMP3["RAMP3"]
    neurodegeneration["neurodegeneration"]
    RAMP3 -->|"implicated_in"| neurodegeneration
    style RAMP3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning RAMP3 in their description or question text

No additional research found