gene

RAPGEF1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAPGEF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🧬 Gene Info

Gene Symbol	RAPGEF1
Full Name	Rap Guanine Nucleotide Exchange Factor 1
Chromosome	9q34.13
Function	is a critical signaling molecule that serves as a guanine nucleotide exchange factor (GEF) for small GTPases Rap1 and R-Ras.
Primary Expression	the central nervous system, particularly in hippocampal neurons, cortical pyramidal cells, and cerebellar Purkinje cells
Molecular Weight	~116 kDa
Amino Acids	047 aa
Exons	23
UniProt ID	Q9Y238
NCBI Gene ID	2889
Ensembl ID	ENSG00000107281
OMIM	600996
GeneCards	RAPGEF1
Human Protein Atlas	RAPGEF1
Alternative Names	C3G, GRF2, CRK SH3-binding guanine nucleotide exchange factor
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RAPGEF1 — AlphaFold Q9Y238 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RAPGEF1["RAPGEF1"]
    neurodegeneration["neurodegeneration"]
    RAPGEF1 -->|"implicated_in"| neurodegeneration
    style RAPGEF1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found