gene

RGS12

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about RGS12: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

RGS12 (Regulator of G Protein Signaling 12) - a multi-domain scaffolding protein that coordinates GPCR signaling in neurons and regulates synaptic plasticity.

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🧬 Gene Info

Gene Symbol	RGS12
Aliases	Regulator of G Protein Signaling 12
Chromosome	10q26.3
Protein Type	Gene
Function	is a member of the RGS protein family that plays critical roles in modulating G protein-coupled receptor (GPCR) signaling in neurons.
Amino Acids	447 aa
GeneCards	RGS12
Human Protein Atlas	RGS12
RGS12-Specific Regions	N-terminal and C-terminal regions contain proline-rich sequences that mediate interactions with SH3 domain-containing proteins including Grb2 and Crk.
Hippocampus	Highest expression in CA1-CA3 pyramidal neurons and dentate gyrus granule cells[@zheng2017]. The hippocampus-dependent learning paradigms strongly implicate RGS12 in memory formation.
Cerebral Cortex	Enriched in layer V pyramidal neurons, consistent with its role in cortico-cortical connectivity and higher cognitive functions.
Basal Ganglia	Moderate expression in striatal medium spiny neurons (MSNs) and substantia nigra pars compacta dopaminergic neurons[@snyder2014], regions pivotal for motor control and Parkinson's disease pathology.
Cerebellum	Expression in Purkinje cells suggests roles in motor learning and coordination.
Postsynaptic Dendrites	Concentrated in dendritic spines where it modulates postsynaptic signaling
Axon Initial Segions	Positioned to regulate action potential initiation
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RGS12 Gene

gene · 1568 words

→

RGS12 Protein

protein · 1680 words

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Pathway Diagram

graph TD
    RGS12["RGS12"]
    neurodegeneration["neurodegeneration"]
    RGS12 -->|"implicated_in"| neurodegeneration
    style RGS12 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
    style neurodegeneration fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning RGS12 in their description or question text

No additional research found