gene

RNF11

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RNF11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

RNF11 is a RING-type E3 ubiquitin ligase that regulates NF-kB signaling, microglial activation, and neuroinflammation in neurodegenerative diseases.

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🧬 Gene Info

Gene Symbol	RNF11
Full Name	RING Finger Protein 11
Aliases	RNF11, MODATOR
Chromosome	1p13.3
Protein Type	Ligase
Function	RNF11 is a modular signaling protein with multiple functional domains that enable it to participate in various cellular processes:
Primary Expression	various tissues, including the brain, and plays important roles in immune response and cell survival
Amino Acids	154 aa
Pathways	nfkb, MAPK Signaling, MAPK
UniProt ID	Q9Y3F4
NCBI Gene ID	26994
GeneCards	RNF11
Human Protein Atlas	RNF11
Protein	RNF11 Protein
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RNF11 — AlphaFold Q9Y3F4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RNF11 — RING Finger Protein 11

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Pathway Diagram

graph TD
    RNF11["RNF11"]
    neurodegeneration["neurodegeneration"]
    RNF11 -->|"implicated_in"| neurodegeneration
    style RNF11 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found