Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RPL39: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
RPL39 (Ribosomal Protein L39) is a component of the 60S ribosomal subunit involved in protein synthesis. Mutations cause Diamond-Blackfan anemia and RPL39 has been implicated in various cancers and neural development.
| Gene Symbol | RPL39 |
| Aliases | Ribosomal Protein L39 |
| Chromosome | Xq24 |
| Function | is a ribosomal protein that functions as a core component of the 60S large ribosomal subunit. |
| Primary Expression | testis, kidney, and neural tissues |
| Subcellular Localization | the cytoplasm, where ribosomes are predominantly found. However, a small fraction is associated with: |
| Molecular Weight | 6 kDa |
| Amino Acids | 51 aa |
| Exons | 4 |
| Ensembl ID | ENSG00000198918 |
| GeneCards | RPL39 |
| Human Protein Atlas | RPL39 |
| Compensatory function | RPL39L can partially compensate for RPL39 deficiency in certain tissues |
| Tissue-specific roles | Higher expression in neuronal cells suggests specialized functions in neural development |
| Cancer association | Altered RPL39L expression has been reported in several cancer types |
| Associated Diseases | Chronic Myeloid Leukemia, Metaplastic Breast Cancer, Pulmonary Arterial Hypertension |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
RPL39(["RPL39"])
Metaplastic_Breast_Cancer["Metaplastic Breast Cancer"]
Glioma["Glioma"]
Proliferation("Proliferation")
Migration("Migration")
Pulmonary_Arterial_Hypertension["Pulmonary Arterial Hypertension"]
Macrophage_Proliferation("Macrophage Proliferation")
Chronic_Myeloid_Leukemia["Chronic Myeloid Leukemia"]
neurodegeneration["neurodegeneration"]
RPL39 -->|"associated with"| Metaplastic_Breast_Cancer
RPL39 -->|"biomarker for"| Glioma
RPL39 -->|"regulates"| Proliferation
RPL39 -->|"regulates"| Migration
RPL39 -->|"associated with"| Pulmonary_Arterial_Hypertension
RPL39 -->|"regulates"| Macrophage_Proliferation
RPL39 -->|"associated with"| Chronic_Myeloid_Leukemia
RPL39 -->|"implicated in"| neurodegeneration
style RPL39 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| Metaplastic Breast Cancer | associated_with | disease | 0.80 |
| Proliferation | regulates | biological_process | 0.80 |
| Migration | regulates | biological_process | 0.80 |
| Pulmonary Arterial Hypertension | associated_with | disease | 0.80 |
| Macrophage Proliferation | regulates | biological_process | 0.80 |
| Chronic Myeloid Leukemia | associated_with | disease | 0.80 |
| Glioma | biomarker_for | disease | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||