disease

Glioma

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Glioma: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

673Connections

0Hypotheses

3Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	IDH1, IDH2, C3AR1, GBM, GLIOBLASTOMA, CANCER, APOPTOSIS, NEURODEGENERATION
Therapeutic Agents	Berberine-inspired Ionizable Lipid, Berberine-Inspired Ionizable Lipid, HDAC inhibitors, Metal complexes (dicyanoargentate-based)
KG Connections	542 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Pathway Diagram

graph TD
    Glioma["<b>Glioma</b>"]
    Als{"Als"}
    Glioma -->|"therapeutic_target"| Als
    Cancer{"Cancer"}
    Glioma -->|"therapeutic_target"| Cancer
    Glioblastoma{"Glioblastoma"}
    Glioma -->|"associated_with"| Glioblastoma
    CANCER(["CANCER"])
    CANCER -->|"therapeutic_target"| Glioma
    Tumor{"Tumor"}
    Tumor -->|"associated_with"| Glioma
    GLIOBLASTOMA(["GLIOBLASTOMA"])
    GLIOBLASTOMA -->|"associated_with"| Glioma
    style Glioma fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0

Outgoing (245)

Target	Relation	Type	Str
Als	therapeutic_target	disease	1.00
Als	activates	disease	1.00
Cancer	therapeutic_target	disease	0.95
Glioblastoma	associated_with	disease	0.95
Glioblastoma	activates	disease	0.95
Glioblastoma	therapeutic_target	disease	0.85
Neurodegeneration	activates	disease	0.85
Als	associated_with	disease	0.85
Stress Granules	associated_with	process	0.80
Autophagy	activates	pathway	0.80
Apoptosis	activates	pathway	0.80
Blood-Brain Barrier	therapeutic_target	pathway	0.80
Stem Cell	activates	pathway	0.80
Cancer	regulates	disease	0.75
Glioblastoma	regulates	disease	0.75
Cancer	activates	disease	0.75
Stem Cell	therapeutic_target	pathway	0.70
Tumor Microenvironment	therapeutic_target	pathway	0.70
Pi3K/Akt	therapeutic_target	pathway	0.70
Apoptosis	therapeutic_target	pathway	0.70
Mtor	activates	pathway	0.70
Chemoresistance	activates	pathway	0.70
Apoptosis	inhibits	pathway	0.70
Invasion	regulates	pathway	0.70
Ferroptosis	activates	pathway	0.70
Invasion	activates	pathway	0.70
Differentiation	activates	pathway	0.70
Mtor	therapeutic_target	pathway	0.65
Als	expressed_in	disease	0.65
Als	regulates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Aging	treats	disease	0.65
Als	inhibits	disease	0.65
Cancer	associated_with	disease	0.65
Aging	therapeutic_target	disease	0.65
Glutamate Signaling	associated_with	pathway	0.60
Tumor Microenvironment	associated_with	pathway	0.60
Drug Resistance	regulates	pathway	0.60
Epithelial-Mesenchymal Transition	therapeutic_target	pathway	0.60
Wnt	therapeutic_target	pathway	0.60
Metastasis	therapeutic_target	pathway	0.60
Nf-Κb	therapeutic_target	pathway	0.60
Multidrug Resistance	therapeutic_target	pathway	0.60
Invasion	associated_with	pathway	0.60
Pi3K/Akt	inhibits	pathway	0.60
Immune Response	therapeutic_target	pathway	0.60
Pyroptosis	therapeutic_target	pathway	0.60
Necroptosis	therapeutic_target	pathway	0.60
Apoptosis	regulates	pathway	0.60
Glycolysis	regulates	pathway	0.60

Incoming (428)

Source	Relation	Type	Str
CANCER	therapeutic_target	gene	1.00
Tumor	associated_with	disease	1.00
Tumor	therapeutic_target	disease	1.00
GLIOBLASTOMA	associated_with	gene	1.00
Tumor	activates	disease	1.00
GLIOBLASTOMA	activates	gene	1.00
NEURODEGENERATION	activates	gene	0.95
LOX	associated_with	gene	0.92
LOXL1	associated_with	gene	0.92
LOXL2	associated_with	gene	0.92
LOXL3	associated_with	gene	0.92
LOXL4	associated_with	gene	0.92
Stress Granules	involved_in	process	0.90
IDH2	biomarker_for	gene	0.90
1p/19q Codeletion	biomarker_for	biomarker	0.90
1P/19Q Codeletion	biomarker_for	biomarker	0.90
Claudins	promotes	protein	0.90
GBM	activates	gene	0.85
EGFR	therapeutic_target	gene	0.85
GBM	therapeutic_target	gene	0.85
MCOLN1	targets	protein	0.85
GLIOBLASTOMA	therapeutic_target	gene	0.85
CANCER	regulates	gene	0.85
AUTOPHAGY	activates	gene	0.85
GLIOBLASTOMA	regulates	gene	0.85
APOPTOSIS	activates	gene	0.85
CANCER	activates	gene	0.85
LOX	biomarker_for	gene	0.85
Lox/Loxl Co-Expressed Genes	biomarker_for	biomarker	0.85
Berberine-Inspired Ionizable Lipid	treats	compound	0.85
Senescence Associated Secretory Phenotype	associated_with	phenotype	0.80
B-series Gangliosides	associated_with	compound	0.80
GSDM Family	biomarker_for	protein	0.80
RPL39	biomarker_for	gene	0.80
Senescence	contributes_to	process	0.80
Berberine-inspired Ionizable Lipid	treats	compound	0.80
LOX/LOXL	targets	enzyme	0.80
PIEZO1	involved_in	protein	0.80
Mutation-Specific Antibodies	biomarker_for	biomarker	0.80
HDAC inhibitors	treats	drug	0.80
Piezo1	implicated_in	protein	0.80
Metal complexes (dicyanoargentate-based)	treats	compound	0.80
CLDN1	downregulates	gene	0.80
CLDN5	downregulates	gene	0.80
BRAF	therapeutic_target	gene	0.75
AKT	therapeutic_target	gene	0.75
MTOR	therapeutic_target	gene	0.75
PI3K	therapeutic_target	gene	0.75
APOPTOSIS	therapeutic_target	gene	0.75
PI3K	activates	gene	0.75

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (3)

Scientific analyses that reference this entity

How does pericyte senescence mechanistically promote glioma cell growth and inva

neurodegeneration | 2026-04-14 | 0 hypotheses

What molecular mechanisms drive neuron-to-glioma synapse formation in high-neura

neuro-oncology | 2026-04-13 | 0 hypotheses

What mechanisms explain how IDH1/IDH2 mutations with reduced enzymatic activity

neurodegeneration | 2026-04-13 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Glioma

Understanding Entity Pages

Wiki Pages (20)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

HNRNPA2B1 Protein

amyloid-beta-metalloproteinases

Blood-Brain Barrier Biology and Crossing Strategies

nf1-protein

Litronesib (LY317615/Enzastaurin)

GLI1 — GLI Family Zinc Finger 1

PAK2 Protein (p21-Activated Kinase 2)

IL1RAP — Interleukin-1 receptor accessory protein

Senolytic Therapies for CBS and [PSP](/diseases/progressive-supranuclear-palsy)

NSUN2 Gene

TNR Gene — Tenascin R

Stress Granules in Neurodegeneration

PLAU Gene (Urokinase)

Blood-Brain Barrier

Hedgehog Signaling in Neurodegeneration

Anti-CASPR2 Encephalitis-Affected Neurons

NanoCarrier Co., Ltd.

H3F3B Gene — H3.3 Histone B

Bulbar Palsy