gene

RPS18

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RPS18: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections

0Hypotheses

0Analyses

15Outgoing

0Incoming

Summary

RPS18 is a gene implicated in neurodegeneration research. Key relationships include: downregulates, upregulates, regulates. Associated with PAAD. Connected to 17 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RPS18
Full Name	Ribosomal Protein S18
Function	encodes a conserved ribosomal protein component of the 40S small ribosomal subunit.
Subcellular Localization	RPS18 is expressed at high levels throughout the brain, particularly in: - Pyram
GeneCards	RPS18
Human Protein Atlas	RPS18
RPS3A	Ribosomal complex
RPS14	Ribosomal complex
RPS19	Ribosomal complex
EIF2B	Translation initiation
UBAP2L	Stress response
LARP1	mRNA regulation
Associated Diseases	PAAD
Interactions	DDX21
KG Connections	15 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RPS18["<b>RPS18</b>"]
    DDX21["DDX21"]
    RPS18 -->|"interacts with"| DDX21
    CSFV["CSFV"]
    RPS18 -->|"participates in"| CSFV
    APOD["APOD"]
    RPS18 -->|"downregulates"| APOD
    SORL1["SORL1"]
    RPS18 -->|"downregulates"| SORL1
    SPOCK2["SPOCK2"]
    RPS18 -->|"downregulates"| SPOCK2
    PRSS11["PRSS11"]
    RPS18 -->|"downregulates"| PRSS11
    ID3["ID3"]
    RPS18 -->|"downregulates"| ID3
    RPS2["RPS2"]
    RPS18 -->|"upregulates"| RPS2
    RPS8["RPS8"]
    RPS18 -->|"upregulates"| RPS8
    RPL37A["RPL37A"]
    RPS18 -->|"upregulates"| RPL37A
    ILF3["ILF3"]
    RPS18 -->|"regulates"| ILF3
    IRF7["IRF7"]
    RPS18 -->|"regulates"| IRF7
    style RPS18 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (15)

Target	Relation	Type	Str
DDX21	interacts_with	gene	0.90
CSFV	participates_in	entity	0.90
SORL1	downregulates	gene	0.80
SPOCK2	downregulates	gene	0.80
PRSS11	downregulates	gene	0.80
ID3	downregulates	gene	0.80
RPS2	upregulates	gene	0.80
RPS8	upregulates	gene	0.80
RPL37A	upregulates	gene	0.80
ILF3	regulates	gene	0.80
IRF7	regulates	gene	0.80
PAAD	associated_with	disease	0.80
M1_macrophage	expressed_in	cell_type	0.80
SPP1	co_expressed_with	gene	0.80
APOD	downregulates	gene	0.80

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

RPS18

Understanding Entity Pages

Summary

Wiki Pages (7)

RPS18 — Ribosomal Protein S18

SORL1 Protein

SORL1 Gene

RPS23 — Ribosomal Protein S23

RPS16 — Ribosomal Protein S16